Plasma clozapine and norclozapine in relation to prescribed dose and other factors in patients aged 65 years and over: data from a therapeutic drug monitoring service, 1996-2010

Objective To investigate the effect of dose and other factors on plasma clozapine concentrations in patients aged 65 years and over. Method Audit of clozapine therapeutic drug monitoring data, 1996–2010. Results There were 1930 samples [778 patients, 363 men aged (median, range) 67 (65–100) years an...

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Veröffentlicht in:	Human psychopharmacology 2012-05, Vol.27 (3), p.277-283
Hauptverfasser:	Bowskill, Sally, Couchman, Lewis, MacCabe, James Hunter, Flanagan, Robert James
Format:	Artikel
Sprache:	eng
Schlagworte:	adherence Adult Age Factors Aged Aged, 80 and over Antipsychotic Agents - blood Clozapine - analogs & derivatives Clozapine - blood clozapine dose requirement clozapine TDM Dose-Response Relationship, Drug Drug Monitoring elderly patients Female Humans Longitudinal Studies Male Mental Disorders - blood Mental Disorders - drug therapy Middle Aged Retrospective Studies Sex Factors smoking
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