Studies on the Synthesis of Di- and Trisaccharide Analogues of Moenomycin A. Modifications in Unit E and in the Lipid Part

Studies on the Synthesis of Di- and Trisaccharide Analogues of Moenomycin A. Modifications in Unit E and in the Lipid Part

Routes allowing the synthesis of moenomycin analogues with one modified sugar component and with new lipid parts were developed (see 10c, 12c, 16b, and 20b in Schemes 2–4). It is anticipated that such analogues will be useful for studying the mode of action of the moenomycin‐type transglycosylase in...

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Veröffentlicht in:Helvetica chimica acta 2004-07, Vol.87 (7), p.1807-1824
Hauptverfasser: Yang, Guangbin, Mansourova, Madina, Hennig, Lothar, Findeisen, Matthias, Oehme, Ramona, Giesa, Sabine, Welzel, Peter
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container_end_page 1824
container_issue 7
container_start_page 1807
container_title Helvetica chimica acta
container_volume 87
creator Yang, Guangbin
Mansourova, Madina
Hennig, Lothar
Findeisen, Matthias
Oehme, Ramona
Giesa, Sabine
Welzel, Peter
description Routes allowing the synthesis of moenomycin analogues with one modified sugar component and with new lipid parts were developed (see 10c, 12c, 16b, and 20b in Schemes 2–4). It is anticipated that such analogues will be useful for studying the mode of action of the moenomycin‐type transglycosylase inhibitors in detail and for preparing analogues with improved pharmacokinetic properties.
doi_str_mv 10.1002/hlca.200490161
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title Studies on the Synthesis of Di- and Trisaccharide Analogues of Moenomycin A. Modifications in Unit E and in the Lipid Part
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