Single-Stranded DNA: Replacement of Canonical by Base-Modified Nucleosides in the Minihairpin 5′-d(GCGAAGC)-3′ and Constructs with the Aptamer 5′-d(GGTTGGTGTGGTTGG)-3

The minihairpin 5′‐d(GCGAAGC)‐3′ (1) was modified either in the loop region, in the base‐paired stem, or at the 5′‐terminus by incorporation of base‐modified nucleosides. The thermal melting was correlated to the structural changes induced by the various donor‐acceptor properties of the nucleosides....

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Veröffentlicht in:	Helvetica chimica acta 2004-02, Vol.87 (2), p.536-553
Hauptverfasser:	Rosemeyer, Helmut, Mokrosch, Verena, Jawalekar, Anup, Becker, Eva-Maria, Seela, Frank
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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