Non-destructive Cleavage of N-Acylsultams Under Neutral Conditions: Preparation of Enantiomerically, Pure Fmoc-Protected α-Amino Acids

Heating diastereoisomerically pure N‐acylsultams 3 or 4 with allyl alcohol/Ti(OR)4 efficiently yields sultams 1 or 2 and allyl esters 5. Esters 5 are hydrolyzed under nonbasic conditions in the presence of Wilkinson's catalyst to give enantiomerically and diastereoisomerically pure carboxylic a...

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Veröffentlicht in:	Helvetica chimica acta 1992-12, Vol.75 (8), p.2572-2582
Hauptverfasser:	Oppolzer, Wolfgang, Lienard, Phillippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Aliphatic compounds Chemistry Exact sciences and technology Organic chemistry Preparations and properties
Online-Zugang:	Volltext
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