Analogues of Sialic Acids as Potential Sialidase Inhibitors. Synthesis of C 6 and C 7 Analogues of N ‐Acetyl‐6‐amino‐2,6‐dideoxyneuraminic Acid
The piperidines 12 – 18 , piperidmose analogues of Neu5Ac ( 1 ) with a shortened side chain, were synthesized from N ‐acetyl‐ D ‐glucosamine via the azidoalkene 32 and tested as inhibitors of Vibrio cholerae sialidase. Deoxygenation at C(4) of the uronate 22 , obtained from the known D ‐GlcNAc deriv...
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| Veröffentlicht in: | Helvetica chimica acta 1991-03, Vol.74 (2), p.343-369 |
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| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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