Cyclische Phenyl‐carbamate des Miotin‐Typs und ihre Wirkung auf die Acetylcholinesterase

Cyclische Phenyl‐carbamate des Miotin‐Typs und ihre Wirkung auf die Acetylcholinesterase

Cyclic Phenyl Carbamates and Their Action on Acetylcholinesterase Several six‐, seven‐, and eight‐membered cyclic phenyl carbamates of the miotin type have been synthesised and their in vitro potency as inhibitors of acetylcholinesterase determined. The eight‐membered rings were found to be the most...

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Veröffentlicht in:Helvetica chimica acta 1990-05, Vol.73 (3), p.739-753
Hauptverfasser: Amstutz, René, Enz, Albert, Marzi, Martin, Boelsterli, Jakob, Walkinshaw, Malcolm
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container_title Helvetica chimica acta
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creator Amstutz, René
Enz, Albert
Marzi, Martin
Boelsterli, Jakob
Walkinshaw, Malcolm
description Cyclic Phenyl Carbamates and Their Action on Acetylcholinesterase Several six‐, seven‐, and eight‐membered cyclic phenyl carbamates of the miotin type have been synthesised and their in vitro potency as inhibitors of acetylcholinesterase determined. The eight‐membered rings were found to be the most potent and are comparable with physostigrnin or miotin. It was concluded that, for maximum potency, the orientation of the carbamate group relative to the aromatic plane has to be close to orthogonal.
doi_str_mv 10.1002/hlca.19900730323
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title Cyclische Phenyl‐carbamate des Miotin‐Typs und ihre Wirkung auf die Acetylcholinesterase
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