Alkaloide aus Evonymus europaea L

From the seeds of Evonymus europaea L. (Celastraceae) the three previously described alkaloids A, B and C were isolated and their empirical formulae determined by mass spectrometry. Alkaloid B, now named evozine, C32H39NO15 (14), alkaloid A, now named evorine, C34H41NO16 (15), and alkaloid C, shown to be identical with Parter's & Libiseller's evonine, C36H43NO17 (17), are respectively tri‐, tetra‐, and penta‐O‐acetyl derivatives of deacetylevonine (13), C26H33NO12. Vigorous alkaline hydrolysis of the latter yields the previously known evonic acid (3). Deacetylevonine (13) is an ester of evonic acid (3) and a hypothetical polyhydroxy compound C15H24O10 (2), which is unstable on alkaline hydrolysis. By partial saponification and partial acetylation, these three alkaloids can be converted into each other, at the same time giving rise to a fourth alkaloid D (16), C34H41NO16, which we name iso‐evorine. This had been obtained already by M. Osowiecki (unpublished).