Protective role of melatonin in domoic acid-induced neuronal damage in the hippocampus of adult rats

Domoic acid (DA), a kainite‐receptor agonist and potent inducer of neurotoxicity, has been administered intravenously in adult rats in the present study (0.75 mg/kg body weight) to demonstrate neuronal degeneration followed by glial activation and their involvement with inducible nitric oxide syntha...

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Veröffentlicht in:	Hippocampus 2003, Vol.13 (3), p.375-387
Hauptverfasser:	Ananth, C., Gopalakrishnakone, P., Kaur, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD Antigens, Neoplasm Antigens, Surface Astrocytes - drug effects Astrocytes - pathology Astrocytes - ultrastructure Avian Proteins Basigin Blood Proteins double immunofluorescence electron microscopy Fluorescent Antibody Technique GFAP Glial Fibrillary Acidic Protein - metabolism Gliosis - drug therapy Gliosis - pathology Gliosis - physiopathology Hippocampus - drug effects Hippocampus - pathology Hippocampus - physiopathology inducible nitric oxide synthase Kainic Acid - analogs & derivatives Kainic Acid - antagonists & inhibitors Kainic Acid - pharmacology Male Melatonin - pharmacology Melatonin - therapeutic use Membrane Glycoproteins - metabolism Microglia - drug effects Microglia - pathology Microglia - ultrastructure Microscopy, Electron Neurodegenerative Diseases - chemically induced Neurodegenerative Diseases - drug therapy Neurodegenerative Diseases - physiopathology Neurons - drug effects Neurons - pathology Neurons - ultrastructure Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Neurotoxins - antagonists & inhibitors Neurotoxins - pharmacology Nitric Oxide - biosynthesis Nitric Oxide Synthase - drug effects Nitric Oxide Synthase - genetics Nitric Oxide Synthase - metabolism OX-42 Pyramidal Cells - drug effects Pyramidal Cells - pathology Pyramidal Cells - ultrastructure rat brain Rats Rats, Wistar Receptors, Kainic Acid - drug effects Receptors, Kainic Acid - metabolism RNA, Messenger - drug effects RNA, Messenger - metabolism RT-PCR
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