Hepatic sinusoidal fibrosis induced by cholesterol and stilbestrol in the rabbit: 2. Hemodynamic and drug disposition studies

We assessed hepatic functions and systemic and splanchnic hemodynamics in a new model of hepatic sinusoidal fibrosis. Fibrosis was induced by the simultaneous administration for 8 weeks of diethyl‐stilbestrol (DES) (10 mg twice weekly, subcutaneously) and cholesterol‐supplemented diet (1%) in rabbit...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 1996-10, Vol.24 (4), p.865-870
Hauptverfasser:	Mastai, R, Laganiere, S, Wanless, I R, Giroux, L, Rocheleau, B, Huet, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Pressure - drug effects Cholesterol, Dietary Diethylstilbestrol Drug toxicity and drugs side effects treatment Heart Rate - drug effects Hemodynamics Liver - blood supply Liver - drug effects Liver - metabolism Liver - physiopathology Liver Cirrhosis, Experimental - chemically induced Liver Cirrhosis, Experimental - metabolism Liver Cirrhosis, Experimental - physiopathology Liver Function Tests Male Medical sciences Organ Size - drug effects Pharmacology. Drug treatments Portal Vein - drug effects Portal Vein - physiopathology Rabbits Toxicity: digestive system
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