αB‐crystallin complexes with 14‐3‐3ζ to induce epithelial‐mesenchymal transition and resistance to sorafenib in hepatocellular carcinoma

The overall survival of patients with hepatocellular carcinoma (HCC) remains poor, and the molecular pathogenesis remains incompletely defined in HCC. Here we report that increased expression of αB‐Crystallin in human HCC predicts poor survival and disease recurrence after surgery. Multivariate anal...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2013-06, Vol.57 (6), p.2235-2247
Hauptverfasser:	Huang, Xiao‐Yong, Ke, Ai‐Wu, Shi, Guo‐Ming, Zhang, Xin, Zhang, Chi, Shi, Ying‐Hong, Wang, Xiao‐Ying, Ding, Zhen‐Bin, Xiao, Yong‐Sheng, Yan, Jun, Qiu, Shuang‐Jian, Fan, Jia, Zhou, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 Proteins - metabolism alpha-Crystallin B Chain - metabolism Antineoplastic Agents - therapeutic use Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Cell Line, Tumor Drug Resistance, Neoplasm Epithelial-Mesenchymal Transition Humans Liver Neoplasms - drug therapy Liver Neoplasms - metabolism MAP Kinase Signaling System Neoplasm Invasiveness Neoplasm Metastasis Niacinamide - analogs & derivatives Niacinamide - therapeutic use Phenylurea Compounds - therapeutic use Proteomics Proto-Oncogene Proteins c-fos - metabolism Snail Family Transcription Factors Transcription Factors - metabolism
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