Treatment of insulin resistance with metformin in naïve genotype 1 chronic hepatitis C patients receiving peginterferon alfa‐2a plus ribavirin

Insulin resistance affects sustained virological response (SVR) in chronic hepatitis C. To know whether adding metformin to standard antiviral treatment improves SVR, we conducted a prospective, multicentered, randomized, double‐blinded, placebo‐controlled trial in 19 Spanish hospitals, including 12...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2009-12, Vol.50 (6), p.1702-1708
Hauptverfasser:	Romero‐Gómez, Manuel, Diago, Moisés, Andrade, Raúl J., Calleja, José L., Salmerón, Javier, Fernández‐Rodríguez, Conrado M., Solà, Ricard, García‐Samaniego, Javier, Herrerías, Juan M., De la Mata, Manuel, Moreno‐Otero, Ricardo, Nuñez, Óscar, Olveira, Antonio, Durán, Santiago, Planas, Ramón
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antiviral Agents - administration & dosage Biological and medical sciences Double-Blind Method Drug Therapy, Combination Female Gastroenterology. Liver. Pancreas. Abdomen Genotype Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - virology Human viral diseases Humans Immunomodulators Infectious diseases Insulin Resistance Interferon-alpha - administration & dosage Interferon-alpha - adverse effects Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Metformin - therapeutic use Middle Aged Pharmacology. Drug treatments Polyethylene Glycols - administration & dosage Polyethylene Glycols - adverse effects PPAR gamma - agonists Recombinant Proteins Ribavirin - administration & dosage Ribavirin - adverse effects Viral diseases Viral hepatitis
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