Methotrexate (MTX) plus ursodeoxycholic acid (UDCA) in the treatment of primary biliary cirrhosis

This placebo-controlled, randomized, multicenter trial compared the effects of MTX plus UDCA to UDCA alone on the course of primary biliary cirrhosis (PBC). Two hundred and sixty five AMA positive patients without ascites, variceal bleeding, or encephalopathy; a serum bilirubin less than 3 mg/dL; se...

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Veröffentlicht in:Hepatology (Baltimore, Md.) Md.), 2005-11, Vol.42 (5), p.1184-1193
Hauptverfasser: COMBES, Burton, EMERSON, Scott S, BENNER, Kent G, KOWDLEY, Kris V, CARITHERS, Robert L, ROSOFF, Leonard JR, GARCIA-TSAO, Guadalupe, BOYER, James L, BOYER, Thomas D, MARTINEZ, Enrique J, BASS, Nathan M, LAKE, John R, FLYE, Nancy L, BARNES, David S, BONACINI, Maurizio, LINDSAY, Karen L, MILLS, A. Scott, MARKIN, Rodney S, RUBIN, Raphael, WEST, A. Brian, WHEELER, Donald E, CONTOS, Melissa J, HOFMANN, Alan F, MUNOZ, Santiago J, LUKETIC, Velimir A, MAYO, Marlyn J, MCCASHLAND, Timothy M, ZETTERMAN, Rowen K, PETERS, Marion G, DI BISCEGLIE, Adrian M
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