Antiviral efficacy of NS3-serine protease inhibitor BILN-2061 in patients with chronic genotype 2 and 3 hepatitis C

BILN-2061, a specific and potent peptidomimetic inhibitor of the HCV NS3 protease, has recently been shown to markedly lower serum hepatitis C virus (HCV)-RNA levels in patients chronically infected with HCV genotype 1 in three 2-day proof of principle studies. The aim of the current study was to as...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2005-04, Vol.41 (4), p.832-835
Hauptverfasser:	REISER, Markus, HINRICHSEN, Holger, BENHAMOU, Yves, REESINK, Henk W, WEDEMEYER, Heiner, AVENDANO, Cristina, RIBA, Neus, YONG, Chan-Loi, NEHMIZ, Gerhard, STEINMANN, Gerhard G
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Carbamates - administration & dosage Carbamates - adverse effects Carbamates - pharmacokinetics Carbamates - therapeutic use Double-Blind Method Drug Administration Schedule Female Fundamental and applied biological sciences. Psychology Genotype Hepacivirus - genetics Hepacivirus - isolation & purification Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - metabolism Hepatitis C, Chronic - virology Human viral diseases Humans Infectious diseases Kinetics Liver. Bile. Biliary tracts Macrocyclic Compounds - administration & dosage Macrocyclic Compounds - adverse effects Macrocyclic Compounds - pharmacokinetics Macrocyclic Compounds - therapeutic use Male Medical sciences Middle Aged Pharmacology. Drug treatments Pilot Projects Prospective Studies Quinolines - administration & dosage Quinolines - adverse effects Quinolines - pharmacokinetics Quinolines - therapeutic use Serine Proteinase Inhibitors - administration & dosage Serine Proteinase Inhibitors - adverse effects Serine Proteinase Inhibitors - pharmacokinetics Serine Proteinase Inhibitors - therapeutic use Thiazoles - administration & dosage Thiazoles - adverse effects Thiazoles - pharmacokinetics Thiazoles - therapeutic use Vertebrates: digestive system Viral diseases Viral hepatitis Viral Load Viral Nonstructural Proteins - antagonists & inhibitors
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