Identification of a Ribavirin‐resistant NS5B mutation of hepatitis C virus during ribavirin monotherapy

Ribavirin (RBV), a guanosine analogue, has been suggested to exert an antiviral action against hepatitis C virus (HCV) by causing lethal mutations and suppressing RNA polymerase in vitro, but the mechanism of its clinical therapeutic effects is currently unknown. To test the hypothesis that RBV coul...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2003-10, Vol.38 (4), p.869-878
Hauptverfasser:	Young, Kung‐Chia, Lindsay, Karen L., Lee, Ki‐Jeong, Liu, Wen‐Chun, He, Jian‐Wen, Milstein, Susan L., Lai, Michael M. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino Acid Sequence Antiviral Agents - pharmacology Binding Sites Biological and medical sciences Drug Resistance, Viral Female Hepacivirus - drug effects Hepacivirus - genetics Hepatitis C - virology Human viral diseases Humans Infectious diseases Interferon-alpha - pharmacology Male Medical sciences Molecular Sequence Data Mutation Ribavirin - pharmacology RNA, Viral - blood Tropical medicine Viral diseases Viral hepatitis Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - genetics Virus Replication - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!