Inactivation of Kupffer cells prevents early alcohol‐induced liver injury

It is well recognized that consumption of alcohol leads to liver disease in a dose‐dependent manner; however, the exact mechanisms remain unclear. Hypoxia subsequent to a hypermetabolic state may be involved; therefore, when it was observed recently that inactivation of Kupffer cells prevented stimu...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 1994-08, Vol.20 (2), p.453-460
Hauptverfasser:	Adachi, Yukito, Bradford, Blair U., Gao, Wenshi, Bojes, Heidi K., Thurman, Ronald G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspartate Aminotransferases - blood Biological and medical sciences Ethanol - toxicity Gadolinium - pharmacology Gastroenterology. Liver. Pancreas. Abdomen Kupffer Cells - drug effects Kupffer Cells - physiology Liver - drug effects Liver - enzymology Liver - pathology Liver Diseases, Alcoholic - enzymology Liver Diseases, Alcoholic - pathology Liver Diseases, Alcoholic - prevention & control Liver. Biliary tract. Portal circulation. Exocrine pancreas Macrophage Activation - drug effects Male Medical sciences Other diseases. Semiology Rats Rats, Wistar
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