Comparative effects of deoxycholate and 7‐methyl‐deoxycholate in the hamster
The metabolism and effect on biliary lipids of a new bile acid analog, 7‐methyl‐deoxycholic acid, were studied and compared with those of deoxycholic acid in the hamster. 14C‐Labeled 7‐methyl‐deoxycholic acid and deoxycholic acid were administered intravenously or intraduodenally to bile fistula ham...
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| Veröffentlicht in: | Hepatology (Baltimore, Md.) Md.), 1987-03, Vol.7 (2), p.229-234 |
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| container_title | Hepatology (Baltimore, Md.) |
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| creator | Kuroki, Syoji Mosbach, Erwin H. Stenger, Richard J. Cohen, Bertram I. McSherry, Charles K. |
| description | The metabolism and effect on biliary lipids of a new bile acid analog, 7‐methyl‐deoxycholic acid, were studied and compared with those of deoxycholic acid in the hamster. 14C‐Labeled 7‐methyl‐deoxycholic acid and deoxycholic acid were administered intravenously or intraduodenally to bile fistula hamsters at 1.0 or 4.0 μmoles per min·kg, and hepatic bile was analyzed for radioactive metabolites and biliary lipid outputs. Deoxycholic acid and 7‐methyl‐deoxycholic acid were efficiently absorbed from the intestine, extracted by the liver and excreted into bile as taurine and glycine conjugates. Twenty per cent of deoxycholic acid was 7α‐hydroxylated to cholic acid while 7‐methyl‐deoxycholic acid did not undergo hydroxylation. During deoxycholic acid infusion, the biliary secretion of phospholipid did not increase, and the bile became more lithogenic. In contrast, 7‐methyl‐deoxycholic acid stimulated phospholipid secretion, and bile became less lithogenic. Although pathologic changes in the liver were inconstant and mostly mild, both bile acids were toxic in the hamster; hemolysis and death due to respiratory distress were observed. |
| doi_str_mv | 10.1002/hep.1840070205 |
| format | Article |
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Deoxycholic acid and 7‐methyl‐deoxycholic acid were efficiently absorbed from the intestine, extracted by the liver and excreted into bile as taurine and glycine conjugates. Twenty per cent of deoxycholic acid was 7α‐hydroxylated to cholic acid while 7‐methyl‐deoxycholic acid did not undergo hydroxylation. During deoxycholic acid infusion, the biliary secretion of phospholipid did not increase, and the bile became more lithogenic. In contrast, 7‐methyl‐deoxycholic acid stimulated phospholipid secretion, and bile became less lithogenic. Although pathologic changes in the liver were inconstant and mostly mild, both bile acids were toxic in the hamster; hemolysis and death due to respiratory distress were observed.</description><identifier>ISSN: 0270-9139</identifier><identifier>EISSN: 1527-3350</identifier><identifier>DOI: 10.1002/hep.1840070205</identifier><identifier>PMID: 3557301</identifier><identifier>CODEN: HPTLD9</identifier><language>eng</language><publisher>Philadelphia, PA: W.B. Saunders</publisher><subject>Animals ; Bile - metabolism ; Bile Acids and Salts - metabolism ; Biological and medical sciences ; Biotransformation ; Cholesterol - metabolism ; Cricetinae ; Deoxycholic Acid - analogs & derivatives ; Deoxycholic Acid - metabolism ; Deoxycholic Acid - pharmacology ; Deoxycholic Acid - toxicity ; General and cellular metabolism. Vitamins ; Male ; Medical sciences ; Mesocricetus ; Pharmacology. Drug treatments</subject><ispartof>Hepatology (Baltimore, Md.), 1987-03, Vol.7 (2), p.229-234</ispartof><rights>Copyright © 1987 American Association for the Study of Liver Diseases</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4095-6753a0e65f75ed620b7dcf66c24cdc63bbe971a514f9e44a86e90843173520a93</citedby><cites>FETCH-LOGICAL-c4095-6753a0e65f75ed620b7dcf66c24cdc63bbe971a514f9e44a86e90843173520a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhep.1840070205$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhep.1840070205$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7466211$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3557301$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuroki, Syoji</creatorcontrib><creatorcontrib>Mosbach, Erwin H.</creatorcontrib><creatorcontrib>Stenger, Richard J.</creatorcontrib><creatorcontrib>Cohen, Bertram I.</creatorcontrib><creatorcontrib>McSherry, Charles K.</creatorcontrib><title>Comparative effects of deoxycholate and 7‐methyl‐deoxycholate in the hamster</title><title>Hepatology (Baltimore, Md.)</title><addtitle>Hepatology</addtitle><description>The metabolism and effect on biliary lipids of a new bile acid analog, 7‐methyl‐deoxycholic acid, were studied and compared with those of deoxycholic acid in the hamster. 14C‐Labeled 7‐methyl‐deoxycholic acid and deoxycholic acid were administered intravenously or intraduodenally to bile fistula hamsters at 1.0 or 4.0 μmoles per min·kg, and hepatic bile was analyzed for radioactive metabolites and biliary lipid outputs. Deoxycholic acid and 7‐methyl‐deoxycholic acid were efficiently absorbed from the intestine, extracted by the liver and excreted into bile as taurine and glycine conjugates. Twenty per cent of deoxycholic acid was 7α‐hydroxylated to cholic acid while 7‐methyl‐deoxycholic acid did not undergo hydroxylation. During deoxycholic acid infusion, the biliary secretion of phospholipid did not increase, and the bile became more lithogenic. In contrast, 7‐methyl‐deoxycholic acid stimulated phospholipid secretion, and bile became less lithogenic. Although pathologic changes in the liver were inconstant and mostly mild, both bile acids were toxic in the hamster; hemolysis and death due to respiratory distress were observed.</description><subject>Animals</subject><subject>Bile - metabolism</subject><subject>Bile Acids and Salts - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biotransformation</subject><subject>Cholesterol - metabolism</subject><subject>Cricetinae</subject><subject>Deoxycholic Acid - analogs & derivatives</subject><subject>Deoxycholic Acid - metabolism</subject><subject>Deoxycholic Acid - pharmacology</subject><subject>Deoxycholic Acid - toxicity</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mesocricetus</subject><subject>Pharmacology. 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Vitamins</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mesocricetus</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuroki, Syoji</creatorcontrib><creatorcontrib>Mosbach, Erwin H.</creatorcontrib><creatorcontrib>Stenger, Richard J.</creatorcontrib><creatorcontrib>Cohen, Bertram I.</creatorcontrib><creatorcontrib>McSherry, Charles K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Hepatology (Baltimore, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuroki, Syoji</au><au>Mosbach, Erwin H.</au><au>Stenger, Richard J.</au><au>Cohen, Bertram I.</au><au>McSherry, Charles K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative effects of deoxycholate and 7‐methyl‐deoxycholate in the hamster</atitle><jtitle>Hepatology (Baltimore, Md.)</jtitle><addtitle>Hepatology</addtitle><date>1987-03</date><risdate>1987</risdate><volume>7</volume><issue>2</issue><spage>229</spage><epage>234</epage><pages>229-234</pages><issn>0270-9139</issn><eissn>1527-3350</eissn><coden>HPTLD9</coden><abstract>The metabolism and effect on biliary lipids of a new bile acid analog, 7‐methyl‐deoxycholic acid, were studied and compared with those of deoxycholic acid in the hamster. 14C‐Labeled 7‐methyl‐deoxycholic acid and deoxycholic acid were administered intravenously or intraduodenally to bile fistula hamsters at 1.0 or 4.0 μmoles per min·kg, and hepatic bile was analyzed for radioactive metabolites and biliary lipid outputs. Deoxycholic acid and 7‐methyl‐deoxycholic acid were efficiently absorbed from the intestine, extracted by the liver and excreted into bile as taurine and glycine conjugates. Twenty per cent of deoxycholic acid was 7α‐hydroxylated to cholic acid while 7‐methyl‐deoxycholic acid did not undergo hydroxylation. During deoxycholic acid infusion, the biliary secretion of phospholipid did not increase, and the bile became more lithogenic. In contrast, 7‐methyl‐deoxycholic acid stimulated phospholipid secretion, and bile became less lithogenic. Although pathologic changes in the liver were inconstant and mostly mild, both bile acids were toxic in the hamster; hemolysis and death due to respiratory distress were observed.</abstract><cop>Philadelphia, PA</cop><pub>W.B. Saunders</pub><pmid>3557301</pmid><doi>10.1002/hep.1840070205</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Hepatology (Baltimore, Md.), 1987-03, Vol.7 (2), p.229-234 |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Animals Bile - metabolism Bile Acids and Salts - metabolism Biological and medical sciences Biotransformation Cholesterol - metabolism Cricetinae Deoxycholic Acid - analogs & derivatives Deoxycholic Acid - metabolism Deoxycholic Acid - pharmacology Deoxycholic Acid - toxicity General and cellular metabolism. Vitamins Male Medical sciences Mesocricetus Pharmacology. Drug treatments |
| title | Comparative effects of deoxycholate and 7‐methyl‐deoxycholate in the hamster |
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