A Prospective Morphologic Evaluation of Hepatic Toxicity of Chenodeoxycholic Acid in Patients with Cholelithiasis: The National Cooperative Gallstone Study

A sample of 126 patients with cholelithiasis was treated with chenodeoxycholic acid (CDCA) (375 or 750 mg g.d.) for 2 years. Hepatotoxicity was assessed by sequential light (LM) and electron microscopic (EM) analysis of liver biopsies obtained before and after 9 and 24 months of therapy. Patients we...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 1982-03, Vol.2 (2), p.187S-201S
Hauptverfasser:	Fisher, Rosemarie L., Anderson, Deborah W., Boyer, James L., Ishak, Kamal, Klatskin, Gerald, Lachin, John M., James Phillips, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biopsy Chenodeoxycholic Acid - adverse effects Cholelithiasis - drug therapy Cholelithiasis - pathology Female Humans Liver - pathology Liver Function Tests Male Microscopy, Electron Random Allocation
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