cis-Platinum and 5-fluorouracil as initial therapy in advanced epidermoid cancers of the head and neck
A total of 44 patients with previously untreated Stage IV squamous cell carcinomas of the head and neck were treated with a combination of cis‐platinum (100 mg/sq m) and 96‐hour infusion of 5‐fluorouracil (5‐FU) (1,000 mg/sq m/day) in two courses or with cis‐platinum (100 mg/sq m) and 120‐hour infus...
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| Veröffentlicht in: | Head & neck surgery (New York, N.Y.) N.Y.), 1982-05, Vol.4 (5), p.370-373 |
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| container_title | Head & neck surgery (New York, N.Y.) |
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| creator | Weaver, Arthur Fleming, Susan Vandenberg, Henry Drelichman, Anibal Jacobs, John Kinzie, Jeannie Loh, John J.-K. Al-Sarraf, Muhyi |
| description | A total of 44 patients with previously untreated Stage IV squamous cell carcinomas of the head and neck were treated with a combination of cis‐platinum (100 mg/sq m) and 96‐hour infusion of 5‐fluorouracil (5‐FU) (1,000 mg/sq m/day) in two courses or with cis‐platinum (100 mg/sq m) and 120‐hour infusion of 5‐FU (1,000 mg/sq m/day) in three courses. In the 26 patients receiving the two course regimen, the tumor response rate was 88.5%. In five of the 26 patients complete disappearance of the tumor was achieved; partial remission was obtained in 18 of 26 patients. The main side effects were nausea and vomiting (70%), leukopenia (27%), and mild‐to‐moderate renal toxicity (27%). In the 18 patients who received the three course regimen of 5‐FU and cis‐platinum, there were 11 (61%) complete responses, 6 (33%) partial responses, and 1 (6%) minimal response. The incidence of complete response was increased with each course given. No added toxicity was observed with surgery or radiotherapy. |
| doi_str_mv | 10.1002/hed.2890040504 |
| format | Article |
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In the 26 patients receiving the two course regimen, the tumor response rate was 88.5%. In five of the 26 patients complete disappearance of the tumor was achieved; partial remission was obtained in 18 of 26 patients. The main side effects were nausea and vomiting (70%), leukopenia (27%), and mild‐to‐moderate renal toxicity (27%). In the 18 patients who received the three course regimen of 5‐FU and cis‐platinum, there were 11 (61%) complete responses, 6 (33%) partial responses, and 1 (6%) minimal response. The incidence of complete response was increased with each course given. 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In the 26 patients receiving the two course regimen, the tumor response rate was 88.5%. In five of the 26 patients complete disappearance of the tumor was achieved; partial remission was obtained in 18 of 26 patients. The main side effects were nausea and vomiting (70%), leukopenia (27%), and mild‐to‐moderate renal toxicity (27%). In the 18 patients who received the three course regimen of 5‐FU and cis‐platinum, there were 11 (61%) complete responses, 6 (33%) partial responses, and 1 (6%) minimal response. The incidence of complete response was increased with each course given. 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| fulltext | fulltext |
| identifier | ISSN: 0148-6403 |
| ispartof | Head & neck surgery (New York, N.Y.), 1982-05, Vol.4 (5), p.370-373 |
| issn | 0148-6403 1930-2398 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_hed_2890040504 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adult Aged Carcinoma, Squamous Cell - drug therapy Cisplatin - adverse effects Cisplatin - therapeutic use Drug Therapy, Combination Female Fluorouracil - adverse effects Fluorouracil - therapeutic use Head and Neck Neoplasms - drug therapy Humans Male Middle Aged |
| title | cis-Platinum and 5-fluorouracil as initial therapy in advanced epidermoid cancers of the head and neck |
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