Integration of chemotherapy in an MFD-radiotherapy plan for advanced inoperable squamous cell carcinoma of the head and neck
From January 1987 to May 1988, 16 patients with advanced squamous cell carcinoma of the head and neck received combined treatment, based on an alternating schedule of chemotherapy and multiple fractions per day (MFD)‐radiotherapy. The chemotherapy regimen consisted of cisplatin, 20 mg/m2, followed b...
Gespeichert in:
| Veröffentlicht in: | Head & neck 1990-01, Vol.12 (1), p.60-65 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 65 |
|---|---|
| container_issue | 1 |
| container_start_page | 60 |
| container_title | Head & neck |
| container_volume | 12 |
| creator | Corvo, Renzo Merlano, Marco Looney, William B. Benasso, Marco Bacigalupo, Almalina Margarino, Giovanni |
| description | From January 1987 to May 1988, 16 patients with advanced squamous cell carcinoma of the head and neck received combined treatment, based on an alternating schedule of chemotherapy and multiple fractions per day (MFD)‐radiotherapy. The chemotherapy regimen consisted of cisplatin, 20 mg/m2, followed by 5‐fluorouracil (5‐FU), 200 mg/m2 i.v. push, from days 1 to 5 during weeks 1, 5, and 9. Radiotherapy was administered in two courses of 32 Gy each (total dose, 64 Gy) during weeks 2 and 3 and 6 and 7. Each course was given in two fractions per day, 5 days per week. The 16 patients were evaluated for toxicity and response. We observed 7 complete responders, 6 partial responders, and 3 nonresponders. The overall response rate was 81%. Toxicity was heavy: 44% of the patients developed grade III‐IV mucositis. Our results suggest that cisplatin and 5‐fluorouracil alternating with MFD‐radiotherapy is effective; however, a new less toxic scheduling must be determinated. |
| doi_str_mv | 10.1002/hed.2880120108 |
| format | Article |
| fullrecord | <record><control><sourceid>wiley_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1002_hed_2880120108</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>HED2880120108</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5028-975ddc63b91bd862de104316e392da4830b637639a3ea0f70281f929b5c88973</originalsourceid><addsrcrecordid>eNqFkEtvGyEUhVHVKK92210lFtmOc4GZAZaRnZfkpF1E6hLdAaaeZl4Bu42l_Phg2XGUVVege853LhxCvjGYMAB-vvBuwpUCxoGB-kSOGWiZgcjl5809F5kAmR-Rkxj_AIAoc35IDjnXqiiLY_Jy2y_974DLZujpUFO78N2wXPiA45o2PcWe3l3NsoCu2Y_HNk3rIVB0f7G33iXjMCataj2NTyvshlWk1rcttRhsEjvcZCeeLjy6FOpo7-3jF3JQYxv91915Sh6uLh-mN9n8x_Xt9GKe2QK4yrQsnLOlqDSrnCq585t_sdILzR3mSkBVClkKjcIj1DIxrNZcV4VVSktxSibbWBuGGIOvzRiaDsPaMDCbEk0q0byXmIDvW2BcVV2S3uy71pJ-ttMxWmzrkFpo4t5WSlCc8WTTW9u_pvXr_yw1N5ezD0_ItmwTl_55z2J4TPFCFubX_bWZzUDB_OedmYpX2LWZ0g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Integration of chemotherapy in an MFD-radiotherapy plan for advanced inoperable squamous cell carcinoma of the head and neck</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Corvo, Renzo ; Merlano, Marco ; Looney, William B. ; Benasso, Marco ; Bacigalupo, Almalina ; Margarino, Giovanni</creator><creatorcontrib>Corvo, Renzo ; Merlano, Marco ; Looney, William B. ; Benasso, Marco ; Bacigalupo, Almalina ; Margarino, Giovanni</creatorcontrib><description>From January 1987 to May 1988, 16 patients with advanced squamous cell carcinoma of the head and neck received combined treatment, based on an alternating schedule of chemotherapy and multiple fractions per day (MFD)‐radiotherapy. The chemotherapy regimen consisted of cisplatin, 20 mg/m2, followed by 5‐fluorouracil (5‐FU), 200 mg/m2 i.v. push, from days 1 to 5 during weeks 1, 5, and 9. Radiotherapy was administered in two courses of 32 Gy each (total dose, 64 Gy) during weeks 2 and 3 and 6 and 7. Each course was given in two fractions per day, 5 days per week. The 16 patients were evaluated for toxicity and response. We observed 7 complete responders, 6 partial responders, and 3 nonresponders. The overall response rate was 81%. Toxicity was heavy: 44% of the patients developed grade III‐IV mucositis. Our results suggest that cisplatin and 5‐fluorouracil alternating with MFD‐radiotherapy is effective; however, a new less toxic scheduling must be determinated.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.2880120108</identifier><identifier>PMID: 2298565</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Carcinoma, Squamous Cell - drug therapy ; Carcinoma, Squamous Cell - radiotherapy ; Carcinoma, Squamous Cell - therapy ; Cisplatin - therapeutic use ; Combined Modality Therapy ; Drug Administration Schedule ; Female ; Fluorouracil - therapeutic use ; Head and Neck Neoplasms - drug therapy ; Head and Neck Neoplasms - radiotherapy ; Head and Neck Neoplasms - therapy ; Humans ; Male ; Medical sciences ; Middle Aged ; Otorhinolaryngology (head neck, general aspects and miscellaneous) ; Otorhinolaryngology. Stomatology ; Tumors</subject><ispartof>Head & neck, 1990-01, Vol.12 (1), p.60-65</ispartof><rights>Copyright © 1990 Wiley Periodicals, Inc., A Wiley Company</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5028-975ddc63b91bd862de104316e392da4830b637639a3ea0f70281f929b5c88973</citedby><cites>FETCH-LOGICAL-c5028-975ddc63b91bd862de104316e392da4830b637639a3ea0f70281f929b5c88973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.2880120108$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.2880120108$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6708212$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2298565$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Corvo, Renzo</creatorcontrib><creatorcontrib>Merlano, Marco</creatorcontrib><creatorcontrib>Looney, William B.</creatorcontrib><creatorcontrib>Benasso, Marco</creatorcontrib><creatorcontrib>Bacigalupo, Almalina</creatorcontrib><creatorcontrib>Margarino, Giovanni</creatorcontrib><title>Integration of chemotherapy in an MFD-radiotherapy plan for advanced inoperable squamous cell carcinoma of the head and neck</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>From January 1987 to May 1988, 16 patients with advanced squamous cell carcinoma of the head and neck received combined treatment, based on an alternating schedule of chemotherapy and multiple fractions per day (MFD)‐radiotherapy. The chemotherapy regimen consisted of cisplatin, 20 mg/m2, followed by 5‐fluorouracil (5‐FU), 200 mg/m2 i.v. push, from days 1 to 5 during weeks 1, 5, and 9. Radiotherapy was administered in two courses of 32 Gy each (total dose, 64 Gy) during weeks 2 and 3 and 6 and 7. Each course was given in two fractions per day, 5 days per week. The 16 patients were evaluated for toxicity and response. We observed 7 complete responders, 6 partial responders, and 3 nonresponders. The overall response rate was 81%. Toxicity was heavy: 44% of the patients developed grade III‐IV mucositis. Our results suggest that cisplatin and 5‐fluorouracil alternating with MFD‐radiotherapy is effective; however, a new less toxic scheduling must be determinated.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - drug therapy</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>Cisplatin - therapeutic use</subject><subject>Combined Modality Therapy</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Fluorouracil - therapeutic use</subject><subject>Head and Neck Neoplasms - drug therapy</subject><subject>Head and Neck Neoplasms - radiotherapy</subject><subject>Head and Neck Neoplasms - therapy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Otorhinolaryngology (head neck, general aspects and miscellaneous)</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Tumors</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtvGyEUhVHVKK92210lFtmOc4GZAZaRnZfkpF1E6hLdAaaeZl4Bu42l_Phg2XGUVVege853LhxCvjGYMAB-vvBuwpUCxoGB-kSOGWiZgcjl5809F5kAmR-Rkxj_AIAoc35IDjnXqiiLY_Jy2y_974DLZujpUFO78N2wXPiA45o2PcWe3l3NsoCu2Y_HNk3rIVB0f7G33iXjMCataj2NTyvshlWk1rcttRhsEjvcZCeeLjy6FOpo7-3jF3JQYxv91915Sh6uLh-mN9n8x_Xt9GKe2QK4yrQsnLOlqDSrnCq585t_sdILzR3mSkBVClkKjcIj1DIxrNZcV4VVSktxSibbWBuGGIOvzRiaDsPaMDCbEk0q0byXmIDvW2BcVV2S3uy71pJ-ttMxWmzrkFpo4t5WSlCc8WTTW9u_pvXr_yw1N5ezD0_ItmwTl_55z2J4TPFCFubX_bWZzUDB_OedmYpX2LWZ0g</recordid><startdate>199001</startdate><enddate>199001</enddate><creator>Corvo, Renzo</creator><creator>Merlano, Marco</creator><creator>Looney, William B.</creator><creator>Benasso, Marco</creator><creator>Bacigalupo, Almalina</creator><creator>Margarino, Giovanni</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>John Wiley & Sons</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199001</creationdate><title>Integration of chemotherapy in an MFD-radiotherapy plan for advanced inoperable squamous cell carcinoma of the head and neck</title><author>Corvo, Renzo ; Merlano, Marco ; Looney, William B. ; Benasso, Marco ; Bacigalupo, Almalina ; Margarino, Giovanni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5028-975ddc63b91bd862de104316e392da4830b637639a3ea0f70281f929b5c88973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - drug therapy</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>Carcinoma, Squamous Cell - therapy</topic><topic>Cisplatin - therapeutic use</topic><topic>Combined Modality Therapy</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Fluorouracil - therapeutic use</topic><topic>Head and Neck Neoplasms - drug therapy</topic><topic>Head and Neck Neoplasms - radiotherapy</topic><topic>Head and Neck Neoplasms - therapy</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Otorhinolaryngology (head neck, general aspects and miscellaneous)</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Corvo, Renzo</creatorcontrib><creatorcontrib>Merlano, Marco</creatorcontrib><creatorcontrib>Looney, William B.</creatorcontrib><creatorcontrib>Benasso, Marco</creatorcontrib><creatorcontrib>Bacigalupo, Almalina</creatorcontrib><creatorcontrib>Margarino, Giovanni</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Corvo, Renzo</au><au>Merlano, Marco</au><au>Looney, William B.</au><au>Benasso, Marco</au><au>Bacigalupo, Almalina</au><au>Margarino, Giovanni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Integration of chemotherapy in an MFD-radiotherapy plan for advanced inoperable squamous cell carcinoma of the head and neck</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>1990-01</date><risdate>1990</risdate><volume>12</volume><issue>1</issue><spage>60</spage><epage>65</epage><pages>60-65</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>From January 1987 to May 1988, 16 patients with advanced squamous cell carcinoma of the head and neck received combined treatment, based on an alternating schedule of chemotherapy and multiple fractions per day (MFD)‐radiotherapy. The chemotherapy regimen consisted of cisplatin, 20 mg/m2, followed by 5‐fluorouracil (5‐FU), 200 mg/m2 i.v. push, from days 1 to 5 during weeks 1, 5, and 9. Radiotherapy was administered in two courses of 32 Gy each (total dose, 64 Gy) during weeks 2 and 3 and 6 and 7. Each course was given in two fractions per day, 5 days per week. The 16 patients were evaluated for toxicity and response. We observed 7 complete responders, 6 partial responders, and 3 nonresponders. The overall response rate was 81%. Toxicity was heavy: 44% of the patients developed grade III‐IV mucositis. Our results suggest that cisplatin and 5‐fluorouracil alternating with MFD‐radiotherapy is effective; however, a new less toxic scheduling must be determinated.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>2298565</pmid><doi>10.1002/hed.2880120108</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1043-3074 |
| ispartof | Head & neck, 1990-01, Vol.12 (1), p.60-65 |
| issn | 1043-3074 1097-0347 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_hed_2880120108 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged Biological and medical sciences Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - radiotherapy Carcinoma, Squamous Cell - therapy Cisplatin - therapeutic use Combined Modality Therapy Drug Administration Schedule Female Fluorouracil - therapeutic use Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - radiotherapy Head and Neck Neoplasms - therapy Humans Male Medical sciences Middle Aged Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Tumors |
| title | Integration of chemotherapy in an MFD-radiotherapy plan for advanced inoperable squamous cell carcinoma of the head and neck |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T13%3A21%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wiley_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Integration%20of%20chemotherapy%20in%20an%20MFD-radiotherapy%20plan%20for%20advanced%20inoperable%20squamous%20cell%20carcinoma%20of%20the%20head%20and%20neck&rft.jtitle=Head%20&%20neck&rft.au=Corvo,%20Renzo&rft.date=1990-01&rft.volume=12&rft.issue=1&rft.spage=60&rft.epage=65&rft.pages=60-65&rft.issn=1043-3074&rft.eissn=1097-0347&rft_id=info:doi/10.1002/hed.2880120108&rft_dat=%3Cwiley_cross%3EHED2880120108%3C/wiley_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/2298565&rfr_iscdi=true |