BUBR1 expression in oral squamous cell carcinoma and its relationship to tumor stage and survival
Background. Defects in the mitotic spindle checkpoint have been proposed to contribute to the chromosomal instability observed in human cancers, including oral squamous cell carcinoma (OSCC). BUBR1 is a key component of the spindle checkpoint, whose role in oral carcinogenesis still needs to be clar...
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| Veröffentlicht in: | Head & neck 2011-05, Vol.33 (5), p.727-733 |
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| creator | Rizzardi, Clara Torelli, Lucio Barresi, Elena Schneider, Manuela Canzonieri, Vincenzo Biasotto, Matteo Di Lenarda, Roberto Melato, Mauro |
| description | Background.
Defects in the mitotic spindle checkpoint have been proposed to contribute to the chromosomal instability observed in human cancers, including oral squamous cell carcinoma (OSCC). BUBR1 is a key component of the spindle checkpoint, whose role in oral carcinogenesis still needs to be clarified.
Methods.
We have analyzed the expression of BUBR1 in 49 cases of OSCC by immunohistochemistry and compared the findings with clinicopathologic parameters, proliferative activity, and DNA ploidy.
Results.
BUBR1 was overexpressed in 11 cases (22.4%). Tumors with overexpression of BUBR1 were associated with a less advanced pathologic stage (p = .05) and showed longer survival periods (p = .38) but shorter recurrence‐free survival periods (p = .13) than those without it.
Conclusions.
Our data imply the possibility that BUBR1 may be involved in the progression of OSCC, and suggest that BUBR1 may be a promising prognostic marker in patients with OSCC. © 2010 Wiley Periodicals, Inc. Head Neck, 2011 |
| doi_str_mv | 10.1002/hed.21532 |
| format | Article |
| fullrecord | <record><control><sourceid>wiley_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1002_hed_21532</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>HED21532</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3922-201847b5fd59a92a6a3de068d1bab5e089ffab564ef36139f8699647c90028593</originalsourceid><addsrcrecordid>eNp1kMlOwzAQhi0EomU58ALIFw4cAt7ixEfaskkIJNTC0ZomNjVkKXbC8vakG5w4za_R989IH0JHlJxRQtj5zORnjMacbaE-JSqJCBfJ9iILHnGSiB7aC-GVEMKlYLuoxyiRKo1JH8FgMnik2HzNvQnB1RV2Fa49FDi8t1DWbcCZKQqcgc9cVZeAocqxawL2poCmK4SZm-Omxk1b1h6HBl7Mkgmt_3AfUBygHQtFMIfruY8mV5fj4U1093B9O7y4izKuGIsYoalIprHNYwWKgQSeGyLTnE5hGhuSKmu7IIWxXFKubCqVkiLJVGcgjRXfR6eru5mvQ_DG6rl3JfhvTYleaNKdJr3U1LHHK3beTstuuyE3XjrgZA1AyKCwHqrMhT9OEEVpknbc-Yr7dIX5_v-jvrkcbV5Hq4YLjfn6bYB_0zLhSayf76_1aMhGT4Pxvb7iP8n5jWM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>BUBR1 expression in oral squamous cell carcinoma and its relationship to tumor stage and survival</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Rizzardi, Clara ; Torelli, Lucio ; Barresi, Elena ; Schneider, Manuela ; Canzonieri, Vincenzo ; Biasotto, Matteo ; Di Lenarda, Roberto ; Melato, Mauro</creator><creatorcontrib>Rizzardi, Clara ; Torelli, Lucio ; Barresi, Elena ; Schneider, Manuela ; Canzonieri, Vincenzo ; Biasotto, Matteo ; Di Lenarda, Roberto ; Melato, Mauro</creatorcontrib><description>Background.
Defects in the mitotic spindle checkpoint have been proposed to contribute to the chromosomal instability observed in human cancers, including oral squamous cell carcinoma (OSCC). BUBR1 is a key component of the spindle checkpoint, whose role in oral carcinogenesis still needs to be clarified.
Methods.
We have analyzed the expression of BUBR1 in 49 cases of OSCC by immunohistochemistry and compared the findings with clinicopathologic parameters, proliferative activity, and DNA ploidy.
Results.
BUBR1 was overexpressed in 11 cases (22.4%). Tumors with overexpression of BUBR1 were associated with a less advanced pathologic stage (p = .05) and showed longer survival periods (p = .38) but shorter recurrence‐free survival periods (p = .13) than those without it.
Conclusions.
Our data imply the possibility that BUBR1 may be involved in the progression of OSCC, and suggest that BUBR1 may be a promising prognostic marker in patients with OSCC. © 2010 Wiley Periodicals, Inc. Head Neck, 2011</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.21532</identifier><identifier>PMID: 21069850</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Aneuploidy ; Biological and medical sciences ; BUBR1 ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Dermatology ; Disease-Free Survival ; Female ; Humans ; Immunohistochemistry ; Male ; Medical sciences ; Middle Aged ; Mouth Neoplasms - metabolism ; Mouth Neoplasms - mortality ; Mouth Neoplasms - pathology ; Neoplasm Recurrence, Local ; oral ; Otorhinolaryngology. Stomatology ; prognostic factor ; Protein-Serine-Threonine Kinases - genetics ; Protein-Serine-Threonine Kinases - metabolism ; spindle checkpoint ; squamous cell carcinoma ; Tumors ; Tumors of the skin and soft tissue. Premalignant lesions ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Head & neck, 2011-05, Vol.33 (5), p.727-733</ispartof><rights>Copyright © 2010 Wiley Periodicals, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3922-201847b5fd59a92a6a3de068d1bab5e089ffab564ef36139f8699647c90028593</citedby><cites>FETCH-LOGICAL-c3922-201847b5fd59a92a6a3de068d1bab5e089ffab564ef36139f8699647c90028593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.21532$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.21532$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24091178$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21069850$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rizzardi, Clara</creatorcontrib><creatorcontrib>Torelli, Lucio</creatorcontrib><creatorcontrib>Barresi, Elena</creatorcontrib><creatorcontrib>Schneider, Manuela</creatorcontrib><creatorcontrib>Canzonieri, Vincenzo</creatorcontrib><creatorcontrib>Biasotto, Matteo</creatorcontrib><creatorcontrib>Di Lenarda, Roberto</creatorcontrib><creatorcontrib>Melato, Mauro</creatorcontrib><title>BUBR1 expression in oral squamous cell carcinoma and its relationship to tumor stage and survival</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background.
Defects in the mitotic spindle checkpoint have been proposed to contribute to the chromosomal instability observed in human cancers, including oral squamous cell carcinoma (OSCC). BUBR1 is a key component of the spindle checkpoint, whose role in oral carcinogenesis still needs to be clarified.
Methods.
We have analyzed the expression of BUBR1 in 49 cases of OSCC by immunohistochemistry and compared the findings with clinicopathologic parameters, proliferative activity, and DNA ploidy.
Results.
BUBR1 was overexpressed in 11 cases (22.4%). Tumors with overexpression of BUBR1 were associated with a less advanced pathologic stage (p = .05) and showed longer survival periods (p = .38) but shorter recurrence‐free survival periods (p = .13) than those without it.
Conclusions.
Our data imply the possibility that BUBR1 may be involved in the progression of OSCC, and suggest that BUBR1 may be a promising prognostic marker in patients with OSCC. © 2010 Wiley Periodicals, Inc. Head Neck, 2011</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aneuploidy</subject><subject>Biological and medical sciences</subject><subject>BUBR1</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Dermatology</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - metabolism</subject><subject>Mouth Neoplasms - mortality</subject><subject>Mouth Neoplasms - pathology</subject><subject>Neoplasm Recurrence, Local</subject><subject>oral</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>prognostic factor</subject><subject>Protein-Serine-Threonine Kinases - genetics</subject><subject>Protein-Serine-Threonine Kinases - metabolism</subject><subject>spindle checkpoint</subject><subject>squamous cell carcinoma</subject><subject>Tumors</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMlOwzAQhi0EomU58ALIFw4cAt7ixEfaskkIJNTC0ZomNjVkKXbC8vakG5w4za_R989IH0JHlJxRQtj5zORnjMacbaE-JSqJCBfJ9iILHnGSiB7aC-GVEMKlYLuoxyiRKo1JH8FgMnik2HzNvQnB1RV2Fa49FDi8t1DWbcCZKQqcgc9cVZeAocqxawL2poCmK4SZm-Omxk1b1h6HBl7Mkgmt_3AfUBygHQtFMIfruY8mV5fj4U1093B9O7y4izKuGIsYoalIprHNYwWKgQSeGyLTnE5hGhuSKmu7IIWxXFKubCqVkiLJVGcgjRXfR6eru5mvQ_DG6rl3JfhvTYleaNKdJr3U1LHHK3beTstuuyE3XjrgZA1AyKCwHqrMhT9OEEVpknbc-Yr7dIX5_v-jvrkcbV5Hq4YLjfn6bYB_0zLhSayf76_1aMhGT4Pxvb7iP8n5jWM</recordid><startdate>201105</startdate><enddate>201105</enddate><creator>Rizzardi, Clara</creator><creator>Torelli, Lucio</creator><creator>Barresi, Elena</creator><creator>Schneider, Manuela</creator><creator>Canzonieri, Vincenzo</creator><creator>Biasotto, Matteo</creator><creator>Di Lenarda, Roberto</creator><creator>Melato, Mauro</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201105</creationdate><title>BUBR1 expression in oral squamous cell carcinoma and its relationship to tumor stage and survival</title><author>Rizzardi, Clara ; Torelli, Lucio ; Barresi, Elena ; Schneider, Manuela ; Canzonieri, Vincenzo ; Biasotto, Matteo ; Di Lenarda, Roberto ; Melato, Mauro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3922-201847b5fd59a92a6a3de068d1bab5e089ffab564ef36139f8699647c90028593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aneuploidy</topic><topic>Biological and medical sciences</topic><topic>BUBR1</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Dermatology</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - metabolism</topic><topic>Mouth Neoplasms - mortality</topic><topic>Mouth Neoplasms - pathology</topic><topic>Neoplasm Recurrence, Local</topic><topic>oral</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>prognostic factor</topic><topic>Protein-Serine-Threonine Kinases - genetics</topic><topic>Protein-Serine-Threonine Kinases - metabolism</topic><topic>spindle checkpoint</topic><topic>squamous cell carcinoma</topic><topic>Tumors</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rizzardi, Clara</creatorcontrib><creatorcontrib>Torelli, Lucio</creatorcontrib><creatorcontrib>Barresi, Elena</creatorcontrib><creatorcontrib>Schneider, Manuela</creatorcontrib><creatorcontrib>Canzonieri, Vincenzo</creatorcontrib><creatorcontrib>Biasotto, Matteo</creatorcontrib><creatorcontrib>Di Lenarda, Roberto</creatorcontrib><creatorcontrib>Melato, Mauro</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rizzardi, Clara</au><au>Torelli, Lucio</au><au>Barresi, Elena</au><au>Schneider, Manuela</au><au>Canzonieri, Vincenzo</au><au>Biasotto, Matteo</au><au>Di Lenarda, Roberto</au><au>Melato, Mauro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BUBR1 expression in oral squamous cell carcinoma and its relationship to tumor stage and survival</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2011-05</date><risdate>2011</risdate><volume>33</volume><issue>5</issue><spage>727</spage><epage>733</epage><pages>727-733</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background.
Defects in the mitotic spindle checkpoint have been proposed to contribute to the chromosomal instability observed in human cancers, including oral squamous cell carcinoma (OSCC). BUBR1 is a key component of the spindle checkpoint, whose role in oral carcinogenesis still needs to be clarified.
Methods.
We have analyzed the expression of BUBR1 in 49 cases of OSCC by immunohistochemistry and compared the findings with clinicopathologic parameters, proliferative activity, and DNA ploidy.
Results.
BUBR1 was overexpressed in 11 cases (22.4%). Tumors with overexpression of BUBR1 were associated with a less advanced pathologic stage (p = .05) and showed longer survival periods (p = .38) but shorter recurrence‐free survival periods (p = .13) than those without it.
Conclusions.
Our data imply the possibility that BUBR1 may be involved in the progression of OSCC, and suggest that BUBR1 may be a promising prognostic marker in patients with OSCC. © 2010 Wiley Periodicals, Inc. Head Neck, 2011</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21069850</pmid><doi>10.1002/hed.21532</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Aneuploidy Biological and medical sciences BUBR1 Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Dermatology Disease-Free Survival Female Humans Immunohistochemistry Male Medical sciences Middle Aged Mouth Neoplasms - metabolism Mouth Neoplasms - mortality Mouth Neoplasms - pathology Neoplasm Recurrence, Local oral Otorhinolaryngology. Stomatology prognostic factor Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism spindle checkpoint squamous cell carcinoma Tumors Tumors of the skin and soft tissue. Premalignant lesions Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | BUBR1 expression in oral squamous cell carcinoma and its relationship to tumor stage and survival |
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