Effects of hyperbaric oxygen exposure on experimental head and neck tumor growth, oxygenation, and vasculature
Background. Hyperbaric oxygen (HBO2) is used to promote healing in irradiated tissues, but concern persists about the possibility that it may promote residual tumor growth. Methods. The tumor growth of SQ20B and Detroit 562 head and neck squamous cell carcinoma xenografts were studied after single‐d...
Gespeichert in:
| Veröffentlicht in: | Head & neck 2005-05, Vol.27 (5), p.362-369 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 369 |
|---|---|
| container_issue | 5 |
| container_start_page | 362 |
| container_title | Head & neck |
| container_volume | 27 |
| creator | Shi, Yuquan Lee, Caroline S. Wu, Junmin Koch, Cameron J. Thom, Stephen R. Maity, Amit Bernhard, Eric J. |
| description | Background.
Hyperbaric oxygen (HBO2) is used to promote healing in irradiated tissues, but concern persists about the possibility that it may promote residual tumor growth.
Methods.
The tumor growth of SQ20B and Detroit 562 head and neck squamous cell carcinoma xenografts were studied after single‐dose irradiation and 5×/week HBO2 treatment at 2.4 atm absolute for 90 minutes. The effect of HBO2 treatment on tumor hypoxia and vasculature was also examined by immunohistochemical analysis.
Results.
HBO2 treatment increased tumor oxygenation during the treatment interval but did not promote the growth of either irradiated or unirradiated tumors. No increase in tumor vascular endothelial growth factor expression or vascularization was detected.
Conclusions.
This study found no evidence for persistent changes in tumor microenvironment or tumor growth promotion caused by hyperbaric oxygen exposure. © 2005 Wiley Periodicals, Inc. Head Neck 27: XXX–XXX, 2005 |
| doi_str_mv | 10.1002/hed.20169 |
| format | Article |
| fullrecord | <record><control><sourceid>wiley_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1002_hed_20169</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>HED20169</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4579-fc0082ee35054bd115c68908687ae91978cd29c478e1dd19137102f30d5e72213</originalsourceid><addsrcrecordid>eNp1kElPwzAQhS0EYj_wB5AvHJAIjO04to-oFIqEWCQQR8t1JjSQJpWdQvvvSRfgxGmeRt-b5RFyxOCcAfCLEebnHFhmNsguA6MSEKnaXOhUJAJUukP2YnwHAJGlfJvsMKmZllLvkrpfFOjbSJuCjuYTDEMXSk-b2fwNa4qzSROnAWmz1BjKMdatq-gIXU5dndMa_Qdtp-Mm0LfQfLWjs7XXtWVTny2ZTxf9tHJtN-iAbBWuini4rvvk5br_3Bskdw83t73Lu8SnUpmk8ACaIwoJMh3mjEmfaQM608qhYUZpn3PjU6WR5TkzTCgGvBCQS1ScM7FPTldzfWhiDFjYSXe7C3PLwC4ys11mdplZxx6v2Ml0OO66v-Q6pA44WQPdI64qgqt9Gf-4TEnIsgV3seK-ygrn_2-0g_7Vz-pk5Shji7NfhwsfNlNCSft6f2NNTz2-Pg2U5eIbEKSSVw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Effects of hyperbaric oxygen exposure on experimental head and neck tumor growth, oxygenation, and vasculature</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Shi, Yuquan ; Lee, Caroline S. ; Wu, Junmin ; Koch, Cameron J. ; Thom, Stephen R. ; Maity, Amit ; Bernhard, Eric J.</creator><creatorcontrib>Shi, Yuquan ; Lee, Caroline S. ; Wu, Junmin ; Koch, Cameron J. ; Thom, Stephen R. ; Maity, Amit ; Bernhard, Eric J.</creatorcontrib><description>Background.
Hyperbaric oxygen (HBO2) is used to promote healing in irradiated tissues, but concern persists about the possibility that it may promote residual tumor growth.
Methods.
The tumor growth of SQ20B and Detroit 562 head and neck squamous cell carcinoma xenografts were studied after single‐dose irradiation and 5×/week HBO2 treatment at 2.4 atm absolute for 90 minutes. The effect of HBO2 treatment on tumor hypoxia and vasculature was also examined by immunohistochemical analysis.
Results.
HBO2 treatment increased tumor oxygenation during the treatment interval but did not promote the growth of either irradiated or unirradiated tumors. No increase in tumor vascular endothelial growth factor expression or vascularization was detected.
Conclusions.
This study found no evidence for persistent changes in tumor microenvironment or tumor growth promotion caused by hyperbaric oxygen exposure. © 2005 Wiley Periodicals, Inc. Head Neck 27: XXX–XXX, 2005</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.20169</identifier><identifier>PMID: 15818558</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Biological and medical sciences ; Carcinoma, Squamous Cell - blood supply ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; Cell Hypoxia ; Dose-Response Relationship, Radiation ; EF-5 ; Head and Neck Neoplasms - blood supply ; Head and Neck Neoplasms - metabolism ; Head and Neck Neoplasms - pathology ; hyperbaric oxygen ; Hyperbaric Oxygenation ; hypoxia ; Immunohistochemistry ; Male ; Medical sciences ; Mice ; Mice, Nude ; Neoplasms, Experimental ; Neovascularization, Pathologic ; Otorhinolaryngology. Stomatology ; radiation ; squamous cell carcinoma ; Transplantation, Heterologous ; Vascular Endothelial Growth Factor A - metabolism</subject><ispartof>Head & neck, 2005-05, Vol.27 (5), p.362-369</ispartof><rights>Copyright © 2005 Wiley Periodicals, Inc.</rights><rights>2005 INIST-CNRS</rights><rights>2005 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4579-fc0082ee35054bd115c68908687ae91978cd29c478e1dd19137102f30d5e72213</citedby><cites>FETCH-LOGICAL-c4579-fc0082ee35054bd115c68908687ae91978cd29c478e1dd19137102f30d5e72213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.20169$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.20169$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16750668$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15818558$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shi, Yuquan</creatorcontrib><creatorcontrib>Lee, Caroline S.</creatorcontrib><creatorcontrib>Wu, Junmin</creatorcontrib><creatorcontrib>Koch, Cameron J.</creatorcontrib><creatorcontrib>Thom, Stephen R.</creatorcontrib><creatorcontrib>Maity, Amit</creatorcontrib><creatorcontrib>Bernhard, Eric J.</creatorcontrib><title>Effects of hyperbaric oxygen exposure on experimental head and neck tumor growth, oxygenation, and vasculature</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background.
Hyperbaric oxygen (HBO2) is used to promote healing in irradiated tissues, but concern persists about the possibility that it may promote residual tumor growth.
Methods.
The tumor growth of SQ20B and Detroit 562 head and neck squamous cell carcinoma xenografts were studied after single‐dose irradiation and 5×/week HBO2 treatment at 2.4 atm absolute for 90 minutes. The effect of HBO2 treatment on tumor hypoxia and vasculature was also examined by immunohistochemical analysis.
Results.
HBO2 treatment increased tumor oxygenation during the treatment interval but did not promote the growth of either irradiated or unirradiated tumors. No increase in tumor vascular endothelial growth factor expression or vascularization was detected.
Conclusions.
This study found no evidence for persistent changes in tumor microenvironment or tumor growth promotion caused by hyperbaric oxygen exposure. © 2005 Wiley Periodicals, Inc. Head Neck 27: XXX–XXX, 2005</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - blood supply</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cell Hypoxia</subject><subject>Dose-Response Relationship, Radiation</subject><subject>EF-5</subject><subject>Head and Neck Neoplasms - blood supply</subject><subject>Head and Neck Neoplasms - metabolism</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>hyperbaric oxygen</subject><subject>Hyperbaric Oxygenation</subject><subject>hypoxia</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Neoplasms, Experimental</subject><subject>Neovascularization, Pathologic</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>radiation</subject><subject>squamous cell carcinoma</subject><subject>Transplantation, Heterologous</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kElPwzAQhS0EYj_wB5AvHJAIjO04to-oFIqEWCQQR8t1JjSQJpWdQvvvSRfgxGmeRt-b5RFyxOCcAfCLEebnHFhmNsguA6MSEKnaXOhUJAJUukP2YnwHAJGlfJvsMKmZllLvkrpfFOjbSJuCjuYTDEMXSk-b2fwNa4qzSROnAWmz1BjKMdatq-gIXU5dndMa_Qdtp-Mm0LfQfLWjs7XXtWVTny2ZTxf9tHJtN-iAbBWuini4rvvk5br_3Bskdw83t73Lu8SnUpmk8ACaIwoJMh3mjEmfaQM608qhYUZpn3PjU6WR5TkzTCgGvBCQS1ScM7FPTldzfWhiDFjYSXe7C3PLwC4ys11mdplZxx6v2Ml0OO66v-Q6pA44WQPdI64qgqt9Gf-4TEnIsgV3seK-ygrn_2-0g_7Vz-pk5Shji7NfhwsfNlNCSft6f2NNTz2-Pg2U5eIbEKSSVw</recordid><startdate>200505</startdate><enddate>200505</enddate><creator>Shi, Yuquan</creator><creator>Lee, Caroline S.</creator><creator>Wu, Junmin</creator><creator>Koch, Cameron J.</creator><creator>Thom, Stephen R.</creator><creator>Maity, Amit</creator><creator>Bernhard, Eric J.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>John Wiley & Sons</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200505</creationdate><title>Effects of hyperbaric oxygen exposure on experimental head and neck tumor growth, oxygenation, and vasculature</title><author>Shi, Yuquan ; Lee, Caroline S. ; Wu, Junmin ; Koch, Cameron J. ; Thom, Stephen R. ; Maity, Amit ; Bernhard, Eric J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4579-fc0082ee35054bd115c68908687ae91978cd29c478e1dd19137102f30d5e72213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - blood supply</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cell Hypoxia</topic><topic>Dose-Response Relationship, Radiation</topic><topic>EF-5</topic><topic>Head and Neck Neoplasms - blood supply</topic><topic>Head and Neck Neoplasms - metabolism</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>hyperbaric oxygen</topic><topic>Hyperbaric Oxygenation</topic><topic>hypoxia</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Neoplasms, Experimental</topic><topic>Neovascularization, Pathologic</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>radiation</topic><topic>squamous cell carcinoma</topic><topic>Transplantation, Heterologous</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shi, Yuquan</creatorcontrib><creatorcontrib>Lee, Caroline S.</creatorcontrib><creatorcontrib>Wu, Junmin</creatorcontrib><creatorcontrib>Koch, Cameron J.</creatorcontrib><creatorcontrib>Thom, Stephen R.</creatorcontrib><creatorcontrib>Maity, Amit</creatorcontrib><creatorcontrib>Bernhard, Eric J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shi, Yuquan</au><au>Lee, Caroline S.</au><au>Wu, Junmin</au><au>Koch, Cameron J.</au><au>Thom, Stephen R.</au><au>Maity, Amit</au><au>Bernhard, Eric J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of hyperbaric oxygen exposure on experimental head and neck tumor growth, oxygenation, and vasculature</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2005-05</date><risdate>2005</risdate><volume>27</volume><issue>5</issue><spage>362</spage><epage>369</epage><pages>362-369</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background.
Hyperbaric oxygen (HBO2) is used to promote healing in irradiated tissues, but concern persists about the possibility that it may promote residual tumor growth.
Methods.
The tumor growth of SQ20B and Detroit 562 head and neck squamous cell carcinoma xenografts were studied after single‐dose irradiation and 5×/week HBO2 treatment at 2.4 atm absolute for 90 minutes. The effect of HBO2 treatment on tumor hypoxia and vasculature was also examined by immunohistochemical analysis.
Results.
HBO2 treatment increased tumor oxygenation during the treatment interval but did not promote the growth of either irradiated or unirradiated tumors. No increase in tumor vascular endothelial growth factor expression or vascularization was detected.
Conclusions.
This study found no evidence for persistent changes in tumor microenvironment or tumor growth promotion caused by hyperbaric oxygen exposure. © 2005 Wiley Periodicals, Inc. Head Neck 27: XXX–XXX, 2005</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15818558</pmid><doi>10.1002/hed.20169</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1043-3074 |
| ispartof | Head & neck, 2005-05, Vol.27 (5), p.362-369 |
| issn | 1043-3074 1097-0347 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_hed_20169 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Animals Biological and medical sciences Carcinoma, Squamous Cell - blood supply Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell Hypoxia Dose-Response Relationship, Radiation EF-5 Head and Neck Neoplasms - blood supply Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology hyperbaric oxygen Hyperbaric Oxygenation hypoxia Immunohistochemistry Male Medical sciences Mice Mice, Nude Neoplasms, Experimental Neovascularization, Pathologic Otorhinolaryngology. Stomatology radiation squamous cell carcinoma Transplantation, Heterologous Vascular Endothelial Growth Factor A - metabolism |
| title | Effects of hyperbaric oxygen exposure on experimental head and neck tumor growth, oxygenation, and vasculature |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T04%3A58%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wiley_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20hyperbaric%20oxygen%20exposure%20on%20experimental%20head%20and%20neck%20tumor%20growth,%20oxygenation,%20and%20vasculature&rft.jtitle=Head%20&%20neck&rft.au=Shi,%20Yuquan&rft.date=2005-05&rft.volume=27&rft.issue=5&rft.spage=362&rft.epage=369&rft.pages=362-369&rft.issn=1043-3074&rft.eissn=1097-0347&rft_id=info:doi/10.1002/hed.20169&rft_dat=%3Cwiley_cross%3EHED20169%3C/wiley_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/15818558&rfr_iscdi=true |