The expression of key cell cycle markers and presence of human papillomavirus in squamous cell carcinoma of the tonsil

Background. Chemical carcinogens induce squamous cell carcinoma (SCC) of the head and neck by targeting the p53 and the retinoblastoma (pRb) pathways. Human papillomavirus (HPV) might have an etiologic role in these cancers at particular sites. Few studies have compared cell cycle protein expression...

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Veröffentlicht in:	Head & neck 2004-01, Vol.26 (1), p.1-9
Hauptverfasser:	Li, Wei, Thompson, Carol H., Cossart, Yvonne E., O'Brien, Christopher J., McNeil, Edward B., Scolyer, Richard A., Rose, Barbara R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aged Biological and medical sciences Biomarkers, Tumor - metabolism Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - virology cell cycle Cyclin D1 - metabolism Cyclin-Dependent Kinase Inhibitor p16 - metabolism DNA, Viral - isolation & purification Down-Regulation Female human papillomavirus Humans Immunohistochemistry Male Medical sciences Microfilament Proteins - metabolism Middle Aged Muscle Proteins Otorhinolaryngology. Stomatology p53 Papillomaviridae - isolation & purification Polymerase Chain Reaction pRb Proto-Oncogene Proteins p21(ras) - metabolism Retinoblastoma Protein - metabolism SCC tonsil Tonsillar Neoplasms - metabolism Tonsillar Neoplasms - virology Up-Regulation
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