Association between smoking during radiotherapy and prognosis in head and neck cancer: A follow-up study
Background. The study objective was to confirm a previous finding that patients with stage III/IV squamous head and neck cancer (SHNC) who smoke during radiotherapy (RT) experience reduced survival. Methods. An observational cohort study. Patients' smoking status was assessed weekly by question...
Gespeichert in:
| Veröffentlicht in: | Head & neck 2002-12, Vol.24 (12), p.1031-1037 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1037 |
|---|---|
| container_issue | 12 |
| container_start_page | 1031 |
| container_title | Head & neck |
| container_volume | 24 |
| creator | Browman, George P. Mohide, E. Ann Willan, Andrew Hodson, Ian Wong, Gene Grimard, Laval MacKenzie, Robert G. El-Sayed, Samy Dunn, Edward Farrell, Sylvia |
| description | Background.
The study objective was to confirm a previous finding that patients with stage III/IV squamous head and neck cancer (SHNC) who smoke during radiotherapy (RT) experience reduced survival.
Methods.
An observational cohort study. Patients' smoking status was assessed weekly by questionnaire plus blood cotinine. Patients were assessed every 3 to 4 months for survival. Logistic regression and Cox proportional hazards analyses were used to detect the independent contribution of smoking on survival.
Results.
Of 148 patients, 113 smoked during RT. Blood cotinine and smoking questionnaire responses were highly correlated (Spearman R = .69; p < .0005). Abstainers and very light smokers experienced better survival than light, moderate, and heavy smokers (median, 42 vs 29 months; p = .07). Tumor and nodal status and years smoked were the most important prognostic factors. Smoking during RT was not an independent predictor of survival, but baseline smoking status was (p = .016).
Conclusion.
Smoking status should be documented in all future trials of RT in SHNC to allow for pooled analyses with sufficient power to address this question. © 2002 Wiley Periodicals, Inc. Head Neck 24: 1031–1037, 2002 |
| doi_str_mv | 10.1002/hed.10168 |
| format | Article |
| fullrecord | <record><control><sourceid>wiley_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1002_hed_10168</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>HED10168</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4258-56b0f0133d0cf335ef8b7cef4c979e4dafdb561183153a9d435e0ba60909e4f03</originalsourceid><addsrcrecordid>eNp1kEtPAjEUhRujEUQX_gHTrYuRW9qZYdwRRDASNQZj4qbp9AEVmE7aIci_d3jIztU5ufc7Z3EQuiZwRwA67ZlWtSFJ9wQ1CWRpBJSlp1vPaEQhZQ10EcI3ANCEdc5Rg3RYzDIGTTTrheCkFZV1Bc51tda6wGHp5raYYrXyW_FCWVfNtBflBotC4dK7aeGCDdgWeKaF2l0LLedYikJqf4972LjFwq2jVYlDtVKbS3RmxCLoq4O20MfjYNIfRePX4VO_N44k68TdKE5yMEAoVSANpbE23TyV2jCZpZlmShiVxwkhXUpiKjLFagRykUAG9dsAbaHbfa_0LgSvDS-9XQq_4QT4di1er8V3a9XszZ4tV_myvh7Jwzw10N4Da7vQm_-b-Gjw8FcZ7RM2VPrnmBB-zpOUpjH_fBny97eUToZfz5zRX30Ng_8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Association between smoking during radiotherapy and prognosis in head and neck cancer: A follow-up study</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Browman, George P. ; Mohide, E. Ann ; Willan, Andrew ; Hodson, Ian ; Wong, Gene ; Grimard, Laval ; MacKenzie, Robert G. ; El-Sayed, Samy ; Dunn, Edward ; Farrell, Sylvia</creator><creatorcontrib>Browman, George P. ; Mohide, E. Ann ; Willan, Andrew ; Hodson, Ian ; Wong, Gene ; Grimard, Laval ; MacKenzie, Robert G. ; El-Sayed, Samy ; Dunn, Edward ; Farrell, Sylvia</creatorcontrib><description>Background.
The study objective was to confirm a previous finding that patients with stage III/IV squamous head and neck cancer (SHNC) who smoke during radiotherapy (RT) experience reduced survival.
Methods.
An observational cohort study. Patients' smoking status was assessed weekly by questionnaire plus blood cotinine. Patients were assessed every 3 to 4 months for survival. Logistic regression and Cox proportional hazards analyses were used to detect the independent contribution of smoking on survival.
Results.
Of 148 patients, 113 smoked during RT. Blood cotinine and smoking questionnaire responses were highly correlated (Spearman R = .69; p < .0005). Abstainers and very light smokers experienced better survival than light, moderate, and heavy smokers (median, 42 vs 29 months; p = .07). Tumor and nodal status and years smoked were the most important prognostic factors. Smoking during RT was not an independent predictor of survival, but baseline smoking status was (p = .016).
Conclusion.
Smoking status should be documented in all future trials of RT in SHNC to allow for pooled analyses with sufficient power to address this question. © 2002 Wiley Periodicals, Inc. Head Neck 24: 1031–1037, 2002</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.10168</identifier><identifier>PMID: 12454940</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Aged ; Carcinoma, Squamous Cell - radiotherapy ; Cohort Studies ; Cotinine - blood ; Female ; Follow-Up Studies ; head and neck cancer neoplasms/radiotherapy ; Head and Neck Neoplasms - radiotherapy ; Humans ; Indicators and Reagents - analysis ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Prognosis ; Proportional Hazards Models ; Radiotherapy - adverse effects ; smoking ; Smoking - adverse effects ; Smoking - blood ; Surveys and Questionnaires ; survival ; Survival Analysis</subject><ispartof>Head & neck, 2002-12, Vol.24 (12), p.1031-1037</ispartof><rights>Copyright © 2002 Wiley Periodicals, Inc.</rights><rights>Copyright 2002 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4258-56b0f0133d0cf335ef8b7cef4c979e4dafdb561183153a9d435e0ba60909e4f03</citedby><cites>FETCH-LOGICAL-c4258-56b0f0133d0cf335ef8b7cef4c979e4dafdb561183153a9d435e0ba60909e4f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.10168$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.10168$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12454940$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Browman, George P.</creatorcontrib><creatorcontrib>Mohide, E. Ann</creatorcontrib><creatorcontrib>Willan, Andrew</creatorcontrib><creatorcontrib>Hodson, Ian</creatorcontrib><creatorcontrib>Wong, Gene</creatorcontrib><creatorcontrib>Grimard, Laval</creatorcontrib><creatorcontrib>MacKenzie, Robert G.</creatorcontrib><creatorcontrib>El-Sayed, Samy</creatorcontrib><creatorcontrib>Dunn, Edward</creatorcontrib><creatorcontrib>Farrell, Sylvia</creatorcontrib><title>Association between smoking during radiotherapy and prognosis in head and neck cancer: A follow-up study</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background.
The study objective was to confirm a previous finding that patients with stage III/IV squamous head and neck cancer (SHNC) who smoke during radiotherapy (RT) experience reduced survival.
Methods.
An observational cohort study. Patients' smoking status was assessed weekly by questionnaire plus blood cotinine. Patients were assessed every 3 to 4 months for survival. Logistic regression and Cox proportional hazards analyses were used to detect the independent contribution of smoking on survival.
Results.
Of 148 patients, 113 smoked during RT. Blood cotinine and smoking questionnaire responses were highly correlated (Spearman R = .69; p < .0005). Abstainers and very light smokers experienced better survival than light, moderate, and heavy smokers (median, 42 vs 29 months; p = .07). Tumor and nodal status and years smoked were the most important prognostic factors. Smoking during RT was not an independent predictor of survival, but baseline smoking status was (p = .016).
Conclusion.
Smoking status should be documented in all future trials of RT in SHNC to allow for pooled analyses with sufficient power to address this question. © 2002 Wiley Periodicals, Inc. Head Neck 24: 1031–1037, 2002</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Cohort Studies</subject><subject>Cotinine - blood</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>head and neck cancer neoplasms/radiotherapy</subject><subject>Head and Neck Neoplasms - radiotherapy</subject><subject>Humans</subject><subject>Indicators and Reagents - analysis</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Radiotherapy - adverse effects</subject><subject>smoking</subject><subject>Smoking - adverse effects</subject><subject>Smoking - blood</subject><subject>Surveys and Questionnaires</subject><subject>survival</subject><subject>Survival Analysis</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtPAjEUhRujEUQX_gHTrYuRW9qZYdwRRDASNQZj4qbp9AEVmE7aIci_d3jIztU5ufc7Z3EQuiZwRwA67ZlWtSFJ9wQ1CWRpBJSlp1vPaEQhZQ10EcI3ANCEdc5Rg3RYzDIGTTTrheCkFZV1Bc51tda6wGHp5raYYrXyW_FCWVfNtBflBotC4dK7aeGCDdgWeKaF2l0LLedYikJqf4972LjFwq2jVYlDtVKbS3RmxCLoq4O20MfjYNIfRePX4VO_N44k68TdKE5yMEAoVSANpbE23TyV2jCZpZlmShiVxwkhXUpiKjLFagRykUAG9dsAbaHbfa_0LgSvDS-9XQq_4QT4di1er8V3a9XszZ4tV_myvh7Jwzw10N4Da7vQm_-b-Gjw8FcZ7RM2VPrnmBB-zpOUpjH_fBny97eUToZfz5zRX30Ng_8</recordid><startdate>200212</startdate><enddate>200212</enddate><creator>Browman, George P.</creator><creator>Mohide, E. Ann</creator><creator>Willan, Andrew</creator><creator>Hodson, Ian</creator><creator>Wong, Gene</creator><creator>Grimard, Laval</creator><creator>MacKenzie, Robert G.</creator><creator>El-Sayed, Samy</creator><creator>Dunn, Edward</creator><creator>Farrell, Sylvia</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200212</creationdate><title>Association between smoking during radiotherapy and prognosis in head and neck cancer: A follow-up study</title><author>Browman, George P. ; Mohide, E. Ann ; Willan, Andrew ; Hodson, Ian ; Wong, Gene ; Grimard, Laval ; MacKenzie, Robert G. ; El-Sayed, Samy ; Dunn, Edward ; Farrell, Sylvia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4258-56b0f0133d0cf335ef8b7cef4c979e4dafdb561183153a9d435e0ba60909e4f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>Cohort Studies</topic><topic>Cotinine - blood</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>head and neck cancer neoplasms/radiotherapy</topic><topic>Head and Neck Neoplasms - radiotherapy</topic><topic>Humans</topic><topic>Indicators and Reagents - analysis</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Radiotherapy - adverse effects</topic><topic>smoking</topic><topic>Smoking - adverse effects</topic><topic>Smoking - blood</topic><topic>Surveys and Questionnaires</topic><topic>survival</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Browman, George P.</creatorcontrib><creatorcontrib>Mohide, E. Ann</creatorcontrib><creatorcontrib>Willan, Andrew</creatorcontrib><creatorcontrib>Hodson, Ian</creatorcontrib><creatorcontrib>Wong, Gene</creatorcontrib><creatorcontrib>Grimard, Laval</creatorcontrib><creatorcontrib>MacKenzie, Robert G.</creatorcontrib><creatorcontrib>El-Sayed, Samy</creatorcontrib><creatorcontrib>Dunn, Edward</creatorcontrib><creatorcontrib>Farrell, Sylvia</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Browman, George P.</au><au>Mohide, E. Ann</au><au>Willan, Andrew</au><au>Hodson, Ian</au><au>Wong, Gene</au><au>Grimard, Laval</au><au>MacKenzie, Robert G.</au><au>El-Sayed, Samy</au><au>Dunn, Edward</au><au>Farrell, Sylvia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between smoking during radiotherapy and prognosis in head and neck cancer: A follow-up study</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2002-12</date><risdate>2002</risdate><volume>24</volume><issue>12</issue><spage>1031</spage><epage>1037</epage><pages>1031-1037</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background.
The study objective was to confirm a previous finding that patients with stage III/IV squamous head and neck cancer (SHNC) who smoke during radiotherapy (RT) experience reduced survival.
Methods.
An observational cohort study. Patients' smoking status was assessed weekly by questionnaire plus blood cotinine. Patients were assessed every 3 to 4 months for survival. Logistic regression and Cox proportional hazards analyses were used to detect the independent contribution of smoking on survival.
Results.
Of 148 patients, 113 smoked during RT. Blood cotinine and smoking questionnaire responses were highly correlated (Spearman R = .69; p < .0005). Abstainers and very light smokers experienced better survival than light, moderate, and heavy smokers (median, 42 vs 29 months; p = .07). Tumor and nodal status and years smoked were the most important prognostic factors. Smoking during RT was not an independent predictor of survival, but baseline smoking status was (p = .016).
Conclusion.
Smoking status should be documented in all future trials of RT in SHNC to allow for pooled analyses with sufficient power to address this question. © 2002 Wiley Periodicals, Inc. Head Neck 24: 1031–1037, 2002</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12454940</pmid><doi>10.1002/hed.10168</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1043-3074 |
| ispartof | Head & neck, 2002-12, Vol.24 (12), p.1031-1037 |
| issn | 1043-3074 1097-0347 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_hed_10168 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adolescent Adult Aged Carcinoma, Squamous Cell - radiotherapy Cohort Studies Cotinine - blood Female Follow-Up Studies head and neck cancer neoplasms/radiotherapy Head and Neck Neoplasms - radiotherapy Humans Indicators and Reagents - analysis Logistic Models Male Middle Aged Multivariate Analysis Prognosis Proportional Hazards Models Radiotherapy - adverse effects smoking Smoking - adverse effects Smoking - blood Surveys and Questionnaires survival Survival Analysis |
| title | Association between smoking during radiotherapy and prognosis in head and neck cancer: A follow-up study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T05%3A31%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wiley_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20smoking%20during%20radiotherapy%20and%20prognosis%20in%20head%20and%20neck%20cancer:%20A%20follow-up%20study&rft.jtitle=Head%20&%20neck&rft.au=Browman,%20George%20P.&rft.date=2002-12&rft.volume=24&rft.issue=12&rft.spage=1031&rft.epage=1037&rft.pages=1031-1037&rft.issn=1043-3074&rft.eissn=1097-0347&rft_id=info:doi/10.1002/hed.10168&rft_dat=%3Cwiley_cross%3EHED10168%3C/wiley_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/12454940&rfr_iscdi=true |