Facile synthesis of 3-spiroindolines
Cyanoacetyldiazoindol‐2‐one (3), the condensation product of cyanoacetohydrazide with isatin (1), could be cyclized in acidic medium via its CN group and its enolic OH to give cyanomethyloxadiazole‐spiroindoline (4). The presence of the methylcyano side chain could be invested—through oximation, di...
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| Veröffentlicht in: | Heteroatom chemistry 2002, Vol.13 (3), p.207-210 |
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| container_title | Heteroatom chemistry |
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| creator | Allam, Yehia A. Nawwar, Galal A. M. |
| description | Cyanoacetyldiazoindol‐2‐one (3), the condensation product of cyanoacetohydrazide with isatin (1), could be cyclized in acidic medium via its CN group and its enolic OH to give cyanomethyloxadiazole‐spiroindoline (4). The presence of the methylcyano side chain could be invested—through oximation, diazotization, or condensation with aldehydes—to form polyfunctional spiroindolines 5, 8–10. Also, a second route for preparing the title compound could be achieved through a nucleophilic attack on position 3 in the isatin derivatives, followed by subsequent ring closure to give 6 and 7. © 2002 Wiley Periodicals, Inc. Heteroatom Chem 13:207–210, 2002; Published online in Wiley Interscience (www.interscience.wiley.com). DOI 10.1002/hc.10020 |
| doi_str_mv | 10.1002/hc.10020 |
| format | Article |
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M.</creatorcontrib><title>Facile synthesis of 3-spiroindolines</title><title>Heteroatom chemistry</title><addtitle>Heteroatom Chem</addtitle><description>Cyanoacetyldiazoindol‐2‐one (3), the condensation product of cyanoacetohydrazide with isatin (1), could be cyclized in acidic medium via its CN group and its enolic OH to give cyanomethyloxadiazole‐spiroindoline (4). The presence of the methylcyano side chain could be invested—through oximation, diazotization, or condensation with aldehydes—to form polyfunctional spiroindolines 5, 8–10. Also, a second route for preparing the title compound could be achieved through a nucleophilic attack on position 3 in the isatin derivatives, followed by subsequent ring closure to give 6 and 7. © 2002 Wiley Periodicals, Inc. Heteroatom Chem 13:207–210, 2002; Published online in Wiley Interscience (www.interscience.wiley.com). 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Also, a second route for preparing the title compound could be achieved through a nucleophilic attack on position 3 in the isatin derivatives, followed by subsequent ring closure to give 6 and 7. © 2002 Wiley Periodicals, Inc. Heteroatom Chem 13:207–210, 2002; Published online in Wiley Interscience (www.interscience.wiley.com). DOI 10.1002/hc.10020</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><doi>10.1002/hc.10020</doi><tpages>4</tpages></addata></record> |
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| title | Facile synthesis of 3-spiroindolines |
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