Depression is associated with low plasma Aβ42 independently of cardiovascular disease in the homebound elderly
Background Depression often precedes the onset of Alzheimer's disease (AD) before the appearance of cognitive symptoms. Plasma Amyloid‐β peptide 42 (Aβ42) declines before and soon after the onset of AD, yet the relationship between plasma Aβ42 and depression is unclear. Methods We used 515 home...
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| Veröffentlicht in: | International journal of geriatric psychiatry 2007-06, Vol.22 (6), p.536-542 |
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| container_title | International journal of geriatric psychiatry |
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| creator | Qiu, Wei Qiao Sun, Xiaoyan Selkoe, Dennis J. Mwamburi, D. Mkaya Huang, Tina Bhadela, Refeeque Bergethon, Peter Scott, Tammy M. Summergrad, Paul Wang, Lixia Rosenberg, Irwin Folstein, Marshal |
| description | Background
Depression often precedes the onset of Alzheimer's disease (AD) before the appearance of cognitive symptoms. Plasma Amyloid‐β peptide 42 (Aβ42) declines before and soon after the onset of AD, yet the relationship between plasma Aβ42 and depression is unclear.
Methods
We used 515 homebound elders aged 60 and older in a population‐based, cross‐sectional study to investigate associations between plasma Aβ levels and depression with and without cardiovascular co‐morbidities. Depression was evaluated by using the Center for Epidemiological Studies Depression (CES‐D) scale. Plasma Aβ40 and Aβ42 were measured.
Results
The elderly with depression had lower plasma Aβ42 (median: 15.3 vs. 18.9, p = 0.008) than those without depression. The CES‐D score was inversely associated with plasma Aβ42 (p = 0.001) in subjects with no cardiovascular disease (CVD); however, in the presence of CVD, this association did not exist. Low plasma Aβ42 (OR = 0.41, p = 0.007) and the presence of CVD (OR = 1.84, p = 0.005) were independently associated with depression after adjusting for the confounders of age, stroke and apolipoprotein E4.
Conclusions
Depressive symptoms are associated with low plasma Aβ42 independently of CVD. Prospective studies are needed to determine whether depression associated with low plasma Aβ42 is a separate depression subtype that could predict the onset of AD. Copyright © 2006 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/gps.1710 |
| format | Article |
| fullrecord | <record><control><sourceid>wiley_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1002_gps_1710</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>GPS1710</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2480-8f8fd553c670ccad7b852492b7f1b8dcc3847aa4984a4754f0a2480114f35a7f3</originalsourceid><addsrcrecordid>eNp10MtOGzEUBmCrKlLTgNRH8KZSNwP2jGfsLFFaAhLiooDozjrxpXHrjEc-AyGvxYPwTEyUqKzY-Cz8nV86PyHfODvmjJUnfzo85pKzT2TE2WRScN40n8mIKVUXTVmxL-Qr4l_Ghj-uRiT9dF12iCG1NCAFxGQC9M7SdeiXNKY17SLgCujp64soaWit69zwtH3c0OSpgWxDegI0jxEytQEdoBsc7ZeOLtPKLdJja6mL1uW4OSQHHiK6o_0ck_uzX3fT8-LyenYxPb0sTCkUK5RX3tZ1ZRrJjAErF6ouxaRcSM8XyhpTKSEBxEQJELIWnsF2j3Phqxqkr8bkxy7X5ISYndddDivIG82Z3halh6L0tqiBft_RbjgCos_QmoDvXqkhVjaDK3ZuHaLbfJinZzfzfe7eB-zd838P-Z9uZCVr_XA10_XvpppO56W-rd4AHjSH3w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Depression is associated with low plasma Aβ42 independently of cardiovascular disease in the homebound elderly</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Qiu, Wei Qiao ; Sun, Xiaoyan ; Selkoe, Dennis J. ; Mwamburi, D. Mkaya ; Huang, Tina ; Bhadela, Refeeque ; Bergethon, Peter ; Scott, Tammy M. ; Summergrad, Paul ; Wang, Lixia ; Rosenberg, Irwin ; Folstein, Marshal</creator><creatorcontrib>Qiu, Wei Qiao ; Sun, Xiaoyan ; Selkoe, Dennis J. ; Mwamburi, D. Mkaya ; Huang, Tina ; Bhadela, Refeeque ; Bergethon, Peter ; Scott, Tammy M. ; Summergrad, Paul ; Wang, Lixia ; Rosenberg, Irwin ; Folstein, Marshal</creatorcontrib><description>Background
Depression often precedes the onset of Alzheimer's disease (AD) before the appearance of cognitive symptoms. Plasma Amyloid‐β peptide 42 (Aβ42) declines before and soon after the onset of AD, yet the relationship between plasma Aβ42 and depression is unclear.
Methods
We used 515 homebound elders aged 60 and older in a population‐based, cross‐sectional study to investigate associations between plasma Aβ levels and depression with and without cardiovascular co‐morbidities. Depression was evaluated by using the Center for Epidemiological Studies Depression (CES‐D) scale. Plasma Aβ40 and Aβ42 were measured.
Results
The elderly with depression had lower plasma Aβ42 (median: 15.3 vs. 18.9, p = 0.008) than those without depression. The CES‐D score was inversely associated with plasma Aβ42 (p = 0.001) in subjects with no cardiovascular disease (CVD); however, in the presence of CVD, this association did not exist. Low plasma Aβ42 (OR = 0.41, p = 0.007) and the presence of CVD (OR = 1.84, p = 0.005) were independently associated with depression after adjusting for the confounders of age, stroke and apolipoprotein E4.
Conclusions
Depressive symptoms are associated with low plasma Aβ42 independently of CVD. Prospective studies are needed to determine whether depression associated with low plasma Aβ42 is a separate depression subtype that could predict the onset of AD. Copyright © 2006 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0885-6230</identifier><identifier>EISSN: 1099-1166</identifier><identifier>DOI: 10.1002/gps.1710</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adult and adolescent clinical studies ; Alzheimer's disease (AD) ; amyloid-β) peptide 42 (Aβ42 ; Biological and medical sciences ; Depression ; Fundamental and applied biological sciences. Psychology ; Geriatrics ; Medical sciences ; Mood disorders ; Psychoanalysis ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry</subject><ispartof>International journal of geriatric psychiatry, 2007-06, Vol.22 (6), p.536-542</ispartof><rights>Copyright © 2006 John Wiley & Sons, Ltd.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2480-8f8fd553c670ccad7b852492b7f1b8dcc3847aa4984a4754f0a2480114f35a7f3</citedby><cites>FETCH-LOGICAL-c2480-8f8fd553c670ccad7b852492b7f1b8dcc3847aa4984a4754f0a2480114f35a7f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fgps.1710$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fgps.1710$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18811476$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Qiu, Wei Qiao</creatorcontrib><creatorcontrib>Sun, Xiaoyan</creatorcontrib><creatorcontrib>Selkoe, Dennis J.</creatorcontrib><creatorcontrib>Mwamburi, D. Mkaya</creatorcontrib><creatorcontrib>Huang, Tina</creatorcontrib><creatorcontrib>Bhadela, Refeeque</creatorcontrib><creatorcontrib>Bergethon, Peter</creatorcontrib><creatorcontrib>Scott, Tammy M.</creatorcontrib><creatorcontrib>Summergrad, Paul</creatorcontrib><creatorcontrib>Wang, Lixia</creatorcontrib><creatorcontrib>Rosenberg, Irwin</creatorcontrib><creatorcontrib>Folstein, Marshal</creatorcontrib><title>Depression is associated with low plasma Aβ42 independently of cardiovascular disease in the homebound elderly</title><title>International journal of geriatric psychiatry</title><addtitle>Int. J. Geriat. Psychiatry</addtitle><description>Background
Depression often precedes the onset of Alzheimer's disease (AD) before the appearance of cognitive symptoms. Plasma Amyloid‐β peptide 42 (Aβ42) declines before and soon after the onset of AD, yet the relationship between plasma Aβ42 and depression is unclear.
Methods
We used 515 homebound elders aged 60 and older in a population‐based, cross‐sectional study to investigate associations between plasma Aβ levels and depression with and without cardiovascular co‐morbidities. Depression was evaluated by using the Center for Epidemiological Studies Depression (CES‐D) scale. Plasma Aβ40 and Aβ42 were measured.
Results
The elderly with depression had lower plasma Aβ42 (median: 15.3 vs. 18.9, p = 0.008) than those without depression. The CES‐D score was inversely associated with plasma Aβ42 (p = 0.001) in subjects with no cardiovascular disease (CVD); however, in the presence of CVD, this association did not exist. Low plasma Aβ42 (OR = 0.41, p = 0.007) and the presence of CVD (OR = 1.84, p = 0.005) were independently associated with depression after adjusting for the confounders of age, stroke and apolipoprotein E4.
Conclusions
Depressive symptoms are associated with low plasma Aβ42 independently of CVD. Prospective studies are needed to determine whether depression associated with low plasma Aβ42 is a separate depression subtype that could predict the onset of AD. Copyright © 2006 John Wiley & Sons, Ltd.</description><subject>Adult and adolescent clinical studies</subject><subject>Alzheimer's disease (AD)</subject><subject>amyloid-β) peptide 42 (Aβ42</subject><subject>Biological and medical sciences</subject><subject>Depression</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Geriatrics</subject><subject>Medical sciences</subject><subject>Mood disorders</subject><subject>Psychoanalysis</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><issn>0885-6230</issn><issn>1099-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNp10MtOGzEUBmCrKlLTgNRH8KZSNwP2jGfsLFFaAhLiooDozjrxpXHrjEc-AyGvxYPwTEyUqKzY-Cz8nV86PyHfODvmjJUnfzo85pKzT2TE2WRScN40n8mIKVUXTVmxL-Qr4l_Ghj-uRiT9dF12iCG1NCAFxGQC9M7SdeiXNKY17SLgCujp64soaWit69zwtH3c0OSpgWxDegI0jxEytQEdoBsc7ZeOLtPKLdJja6mL1uW4OSQHHiK6o_0ck_uzX3fT8-LyenYxPb0sTCkUK5RX3tZ1ZRrJjAErF6ouxaRcSM8XyhpTKSEBxEQJELIWnsF2j3Phqxqkr8bkxy7X5ISYndddDivIG82Z3halh6L0tqiBft_RbjgCos_QmoDvXqkhVjaDK3ZuHaLbfJinZzfzfe7eB-zd838P-Z9uZCVr_XA10_XvpppO56W-rd4AHjSH3w</recordid><startdate>200706</startdate><enddate>200706</enddate><creator>Qiu, Wei Qiao</creator><creator>Sun, Xiaoyan</creator><creator>Selkoe, Dennis J.</creator><creator>Mwamburi, D. Mkaya</creator><creator>Huang, Tina</creator><creator>Bhadela, Refeeque</creator><creator>Bergethon, Peter</creator><creator>Scott, Tammy M.</creator><creator>Summergrad, Paul</creator><creator>Wang, Lixia</creator><creator>Rosenberg, Irwin</creator><creator>Folstein, Marshal</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200706</creationdate><title>Depression is associated with low plasma Aβ42 independently of cardiovascular disease in the homebound elderly</title><author>Qiu, Wei Qiao ; Sun, Xiaoyan ; Selkoe, Dennis J. ; Mwamburi, D. Mkaya ; Huang, Tina ; Bhadela, Refeeque ; Bergethon, Peter ; Scott, Tammy M. ; Summergrad, Paul ; Wang, Lixia ; Rosenberg, Irwin ; Folstein, Marshal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2480-8f8fd553c670ccad7b852492b7f1b8dcc3847aa4984a4754f0a2480114f35a7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Alzheimer's disease (AD)</topic><topic>amyloid-β) peptide 42 (Aβ42</topic><topic>Biological and medical sciences</topic><topic>Depression</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Geriatrics</topic><topic>Medical sciences</topic><topic>Mood disorders</topic><topic>Psychoanalysis</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qiu, Wei Qiao</creatorcontrib><creatorcontrib>Sun, Xiaoyan</creatorcontrib><creatorcontrib>Selkoe, Dennis J.</creatorcontrib><creatorcontrib>Mwamburi, D. Mkaya</creatorcontrib><creatorcontrib>Huang, Tina</creatorcontrib><creatorcontrib>Bhadela, Refeeque</creatorcontrib><creatorcontrib>Bergethon, Peter</creatorcontrib><creatorcontrib>Scott, Tammy M.</creatorcontrib><creatorcontrib>Summergrad, Paul</creatorcontrib><creatorcontrib>Wang, Lixia</creatorcontrib><creatorcontrib>Rosenberg, Irwin</creatorcontrib><creatorcontrib>Folstein, Marshal</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>International journal of geriatric psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qiu, Wei Qiao</au><au>Sun, Xiaoyan</au><au>Selkoe, Dennis J.</au><au>Mwamburi, D. Mkaya</au><au>Huang, Tina</au><au>Bhadela, Refeeque</au><au>Bergethon, Peter</au><au>Scott, Tammy M.</au><au>Summergrad, Paul</au><au>Wang, Lixia</au><au>Rosenberg, Irwin</au><au>Folstein, Marshal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Depression is associated with low plasma Aβ42 independently of cardiovascular disease in the homebound elderly</atitle><jtitle>International journal of geriatric psychiatry</jtitle><addtitle>Int. J. Geriat. Psychiatry</addtitle><date>2007-06</date><risdate>2007</risdate><volume>22</volume><issue>6</issue><spage>536</spage><epage>542</epage><pages>536-542</pages><issn>0885-6230</issn><eissn>1099-1166</eissn><abstract>Background
Depression often precedes the onset of Alzheimer's disease (AD) before the appearance of cognitive symptoms. Plasma Amyloid‐β peptide 42 (Aβ42) declines before and soon after the onset of AD, yet the relationship between plasma Aβ42 and depression is unclear.
Methods
We used 515 homebound elders aged 60 and older in a population‐based, cross‐sectional study to investigate associations between plasma Aβ levels and depression with and without cardiovascular co‐morbidities. Depression was evaluated by using the Center for Epidemiological Studies Depression (CES‐D) scale. Plasma Aβ40 and Aβ42 were measured.
Results
The elderly with depression had lower plasma Aβ42 (median: 15.3 vs. 18.9, p = 0.008) than those without depression. The CES‐D score was inversely associated with plasma Aβ42 (p = 0.001) in subjects with no cardiovascular disease (CVD); however, in the presence of CVD, this association did not exist. Low plasma Aβ42 (OR = 0.41, p = 0.007) and the presence of CVD (OR = 1.84, p = 0.005) were independently associated with depression after adjusting for the confounders of age, stroke and apolipoprotein E4.
Conclusions
Depressive symptoms are associated with low plasma Aβ42 independently of CVD. Prospective studies are needed to determine whether depression associated with low plasma Aβ42 is a separate depression subtype that could predict the onset of AD. Copyright © 2006 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><doi>10.1002/gps.1710</doi><tpages>7</tpages></addata></record> |
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| ispartof | International journal of geriatric psychiatry, 2007-06, Vol.22 (6), p.536-542 |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Adult and adolescent clinical studies Alzheimer's disease (AD) amyloid-β) peptide 42 (Aβ42 Biological and medical sciences Depression Fundamental and applied biological sciences. Psychology Geriatrics Medical sciences Mood disorders Psychoanalysis Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry |
| title | Depression is associated with low plasma Aβ42 independently of cardiovascular disease in the homebound elderly |
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