Microglial TNF-α mediates enhancement of dopaminergic degeneration by brain angiotensin

In vitro and in vivo models of Parkinson's disease were used to investigate whether TNF‐α plays a major role in the enhancement of the microglial response and dopaminergic degeneration induced by brain angiotensin hyperactivity. Treatment of primary mesencephalic cultures with low doses of the...

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Veröffentlicht in:	Glia 2014-01, Vol.62 (1), p.145-157
Hauptverfasser:	Borrajo, Ana, Rodriguez-Perez, Ana I., Diaz-Ruiz, Carmen, Guerra, Maria J., Labandeira-Garcia, Jose L.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology Angiotensin II - pharmacology Angiotensin II Type 1 Receptor Blockers - pharmacology Animals Benzimidazoles - pharmacology Cells, Cultured Cyclic CMP - analogs & derivatives Cyclic CMP - pharmacology dopamine Dopaminergic Neurons - drug effects Dopaminergic Neurons - pathology Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology glia Kallikreins - metabolism Male Mesencephalon - cytology Mice Mice, Inbred C57BL Microglia - metabolism NADPH-oxidase Nerve Degeneration - chemically induced Nerve Degeneration - metabolism Nerve Degeneration - physiopathology neuroinflammation Neurons - drug effects Neurons - physiology Neurotoxins - pharmacology oxidative stress Pancreatic Extracts - metabolism Parkinson Tetrazoles - pharmacology Tumor Necrosis Factor-alpha - metabolism
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