Occurrence of a non deleterious gene conversion event in the BRCA 1 gene

The duplication in the primate lineage of a portion of the breast and ovarian cancer susceptibility gene BRCA1 has created a BRCA1 pseudogene 45 kb away. Non‐allelic homologous recombination (NAHR) between BRCA1 and BRCA1P1 has generated recurrent deleterious germ‐line 37‐kb deletions encompassing t...

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Veröffentlicht in:	Genes chromosomes & cancer 2015-10, Vol.54 (10), p.646-652
Hauptverfasser:	Tessereau, Chloé, Léoné, Mélanie, Buisson, Monique, Duret, Laurent, Sinilnikova, Olga M., Mazoyer, Sylvie
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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