Differential TERT promoter methylation and response to 5-aza-2′-deoxycytidine in acute myeloid leukemia cell lines: TERT expression, telomerase activity, telomere length, and cell death

The catalytic subunit of human telomerase (TERT) is highly expressed in cancer cells, and correlates with complex cytogenetics and disease severity in acute myeloid leukemia (AML). The TERT promoter is situated within a large CpG island, suggesting that expression is methylation‐sensitive. Studies s...

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Veröffentlicht in:	Genes chromosomes & cancer 2012-08, Vol.51 (8), p.768-780
Hauptverfasser:	Pettigrew, Kerry A., Armstrong, Richard N., Colyer, Hilary A. A., Zhang, Shu-Dong, Rea, Irene Maeve, Jones, Rhiannon E., Baird, Duncan M., Mills, Ken I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged, 80 and over Antimetabolites, Antineoplastic - pharmacology Azacitidine - analogs & derivatives Azacitidine - pharmacology Cell Death - drug effects Cell Death - genetics Cell Line, Tumor CpG Islands DNA Methylation Female Gene Expression Regulation, Neoplastic HL-60 Cells Humans Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology Male Promoter Regions, Genetic Telomerase - biosynthesis Telomerase - genetics Telomerase - metabolism Telomere - genetics U937 Cells
Online-Zugang:	Volltext
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