SCE induction is uncoupled from mutation induction in mammalian cells following exposure to ethylnitrosourea (ENU)

It has been suggested not only that sister chromatid exchange (SCE) induction might serve as a qualitative indicator of mutagenesis, but also that induced SCE frequencies are linearly related to induced mutation frequencies. The consistency of the relationship between SCEs and mutations was tested i...

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Veröffentlicht in:	Environ. Mutagen.; (United States) 1985, Vol.7 (2), p.233-243
Hauptverfasser:	Stetka Jr, Daniel G., Bleicher Jr, William T., Brewen, J. Grant
Format:	Artikel
Sprache:	eng
Schlagworte:	560301 - Chemicals Metabolism & Toxicology- Cells- (-1987) ANIMAL CELLS Animals BIOLOGICAL EFFECTS CELL CYCLE Cells, Cultured CHO CELLS CHROMOSOMAL ABERRATIONS Cricetinae Cricetulus DNA Repair ethylnitrosourea (ENU) Ethylnitrosourea - toxicity Female GENETIC EFFECTS mammalian cells MUTAGENESIS Mutation MUTATION FREQUENCY MUTATIONS NITROSO COMPOUNDS Nitrosourea Compounds - toxicity NITROSOUREAS ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT SCEs Sister Chromatid Exchange - drug effects SISTER CHROMATID EXCHANGES
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