Genetic effects of methylmercury in human chromosomes: I. A cytogenetic study of people exposed through eating contaminated fish
An analysis of chromosomal aberrations (structural and numerical) and sister chromatid exchange (SCE) was carried out on 16 people exposed to methylmercury through eating fish caught in Cartagena Bay (Colombia), an area of known methylmercury contamination. Fourteen people whose diet consisted mainl...
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| Veröffentlicht in: | Environ. Mol. Mutagen.; (United States) 1987, Vol.10 (4), p.367-376 |
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| description | An analysis of chromosomal aberrations (structural and numerical) and sister chromatid exchange (SCE) was carried out on 16 people exposed to methylmercury through eating fish caught in Cartagena Bay (Colombia), an area of known methylmercury contamination. Fourteen people whose diet consisted mainly of fish caught in another, noncontaminated area of the Atlantic acted as controls. The results showed a significant difference between the experimental and control groups in methylmercury (MM) concentrations measured in hair and peripheral blood. Subsequently, significant differences between levels of organic mercury in blood and hair were found when all the individuals studied were classified in two groups according to their blood mercury levels. When achromatic lesions were included, the frequency of structural chromosome aberrations differed significantly between the exposed and control groups. Furthermore, a significant correlation (p < 0.05) was found between structural chromosome aberrations and groups (exposed and control). When achromatic lesions were excluded from the analyses, these differences were not found. There was a significant correlation between SCE and age. This is the first report of a study on the frequency of SCE in a population exposed to methylmercury. |
| doi_str_mv | 10.1002/em.2850100406 |
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A cytogenetic study of people exposed through eating contaminated fish</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Monsalve, M. V. ; Chiappe, C.</creator><creatorcontrib>Monsalve, M. V. ; Chiappe, C. ; Universidad de los Andes, Bogota (Colombia)</creatorcontrib><description>An analysis of chromosomal aberrations (structural and numerical) and sister chromatid exchange (SCE) was carried out on 16 people exposed to methylmercury through eating fish caught in Cartagena Bay (Colombia), an area of known methylmercury contamination. Fourteen people whose diet consisted mainly of fish caught in another, noncontaminated area of the Atlantic acted as controls. The results showed a significant difference between the experimental and control groups in methylmercury (MM) concentrations measured in hair and peripheral blood. Subsequently, significant differences between levels of organic mercury in blood and hair were found when all the individuals studied were classified in two groups according to their blood mercury levels. When achromatic lesions were included, the frequency of structural chromosome aberrations differed significantly between the exposed and control groups. Furthermore, a significant correlation (p < 0.05) was found between structural chromosome aberrations and groups (exposed and control). When achromatic lesions were excluded from the analyses, these differences were not found. There was a significant correlation between SCE and age. This is the first report of a study on the frequency of SCE in a population exposed to methylmercury.</description><identifier>ISSN: 0893-6692</identifier><identifier>EISSN: 1098-2280</identifier><identifier>DOI: 10.1002/em.2850100406</identifier><identifier>PMID: 3678208</identifier><identifier>CODEN: EMMUEG</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>560300 - Chemicals Metabolism & Toxicology ; AGE DEPENDENCE ; ANIMALS ; AQUATIC ORGANISMS ; Biological and medical sciences ; BIOLOGICAL EFFECTS ; BIOLOGICAL MATERIALS ; BIOLOGY ; BLOOD ; blood mercury levels ; BODY ; BODY FLUIDS ; Chemical mutagenesis ; CHROMOSOMAL ABERRATIONS ; Chromosome Aberrations ; COLOMBIA ; CONTAMINATION ; CYTOLOGY ; DIET ; FISHES ; Food Contamination ; GENETIC EFFECTS ; HAIR ; Hair - analysis ; hair mercury levels ; Humans ; INGESTION ; INTAKE ; LATIN AMERICA ; Lymphocytes - ultrastructure ; MAMMALS ; MAN ; MATERIALS ; Medical sciences ; MERCURY COMPOUNDS ; METHYLMERCURY ; Methylmercury Compounds - analysis ; Methylmercury Compounds - blood ; Methylmercury Compounds - pharmacology ; MUTATION FREQUENCY ; MUTATIONS ; ORGANIC COMPOUNDS ; ORGANIC MERCURY COMPOUNDS ; ORGANS ; PRIMATES ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; sister chromatid exchange ; Sister Chromatid Exchange - drug effects ; SISTER CHROMATID EXCHANGES ; SKIN ; SOUTH AMERICA ; Toxicology ; VERTEBRATES</subject><ispartof>Environ. Mol. 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V.</creatorcontrib><creatorcontrib>Chiappe, C.</creatorcontrib><creatorcontrib>Universidad de los Andes, Bogota (Colombia)</creatorcontrib><title>Genetic effects of methylmercury in human chromosomes: I. A cytogenetic study of people exposed through eating contaminated fish</title><title>Environ. Mol. Mutagen.; (United States)</title><addtitle>Environ. Mol. Mutagen</addtitle><description>An analysis of chromosomal aberrations (structural and numerical) and sister chromatid exchange (SCE) was carried out on 16 people exposed to methylmercury through eating fish caught in Cartagena Bay (Colombia), an area of known methylmercury contamination. Fourteen people whose diet consisted mainly of fish caught in another, noncontaminated area of the Atlantic acted as controls. The results showed a significant difference between the experimental and control groups in methylmercury (MM) concentrations measured in hair and peripheral blood. Subsequently, significant differences between levels of organic mercury in blood and hair were found when all the individuals studied were classified in two groups according to their blood mercury levels. When achromatic lesions were included, the frequency of structural chromosome aberrations differed significantly between the exposed and control groups. Furthermore, a significant correlation (p < 0.05) was found between structural chromosome aberrations and groups (exposed and control). When achromatic lesions were excluded from the analyses, these differences were not found. There was a significant correlation between SCE and age. This is the first report of a study on the frequency of SCE in a population exposed to methylmercury.</description><subject>560300 - Chemicals Metabolism & Toxicology</subject><subject>AGE DEPENDENCE</subject><subject>ANIMALS</subject><subject>AQUATIC ORGANISMS</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIOLOGICAL MATERIALS</subject><subject>BIOLOGY</subject><subject>BLOOD</subject><subject>blood mercury levels</subject><subject>BODY</subject><subject>BODY FLUIDS</subject><subject>Chemical mutagenesis</subject><subject>CHROMOSOMAL ABERRATIONS</subject><subject>Chromosome Aberrations</subject><subject>COLOMBIA</subject><subject>CONTAMINATION</subject><subject>CYTOLOGY</subject><subject>DIET</subject><subject>FISHES</subject><subject>Food Contamination</subject><subject>GENETIC EFFECTS</subject><subject>HAIR</subject><subject>Hair - analysis</subject><subject>hair mercury levels</subject><subject>Humans</subject><subject>INGESTION</subject><subject>INTAKE</subject><subject>LATIN AMERICA</subject><subject>Lymphocytes - ultrastructure</subject><subject>MAMMALS</subject><subject>MAN</subject><subject>MATERIALS</subject><subject>Medical sciences</subject><subject>MERCURY COMPOUNDS</subject><subject>METHYLMERCURY</subject><subject>Methylmercury Compounds - analysis</subject><subject>Methylmercury Compounds - blood</subject><subject>Methylmercury Compounds - pharmacology</subject><subject>MUTATION FREQUENCY</subject><subject>MUTATIONS</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC MERCURY COMPOUNDS</subject><subject>ORGANS</subject><subject>PRIMATES</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>sister chromatid exchange</subject><subject>Sister Chromatid Exchange - drug effects</subject><subject>SISTER CHROMATID EXCHANGES</subject><subject>SKIN</subject><subject>SOUTH AMERICA</subject><subject>Toxicology</subject><subject>VERTEBRATES</subject><issn>0893-6692</issn><issn>1098-2280</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtv1DAUhS0EKkNhyRLJQmwz-BE_wq6q2mlReSxALC2P53piiONR7Ihmx09vqokGsWHlK53vXJ97EHpNyZoSwt5DXDMtyDzXRD5BK0oaXTGmyVO0IrrhlZQNe45e5PyTEErrhp2hMy6VZkSv0J8N9FCCw-A9uJJx8jhCaacuwuDGYcKhx-0YbY9dO6SYcoqQP-DbNb7Abippv_hzGXfTo_sA6dABhvtDyrDDZXaN-xaDLaHfY5f6YmPobZk1H3L7Ej3ztsvwannP0ffrq2-XN9Xdl83t5cVd5WpKZeUABHFit1USQIKXYKmgVGuqtiC9lby2nHCmBHWOEQ9WNhws0UKorSCMn6O3x70pl2CyCwVcO6fp56uNorohXM1QdYTckHIewJvDEKIdJkOJeWzbQDR_2575N0f-MG4j7E70Uu-sv1t0m53t_GB7F_IJU1ITVosZU0fsd-hg-v-f5urTPwGWwCEXuD857fDLSMWVMD8-b4wU17z-KKn5yh8ArWKnag</recordid><startdate>1987</startdate><enddate>1987</enddate><creator>Monsalve, M. V.</creator><creator>Chiappe, C.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>1987</creationdate><title>Genetic effects of methylmercury in human chromosomes: I. A cytogenetic study of people exposed through eating contaminated fish</title><author>Monsalve, M. V. ; Chiappe, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4116-cee50c5db76ee6ef6ea15118817be6fa634a3032751cc20fea693ea08557b5023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>560300 - Chemicals Metabolism & Toxicology</topic><topic>AGE DEPENDENCE</topic><topic>ANIMALS</topic><topic>AQUATIC ORGANISMS</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BIOLOGICAL MATERIALS</topic><topic>BIOLOGY</topic><topic>BLOOD</topic><topic>blood mercury levels</topic><topic>BODY</topic><topic>BODY FLUIDS</topic><topic>Chemical mutagenesis</topic><topic>CHROMOSOMAL ABERRATIONS</topic><topic>Chromosome Aberrations</topic><topic>COLOMBIA</topic><topic>CONTAMINATION</topic><topic>CYTOLOGY</topic><topic>DIET</topic><topic>FISHES</topic><topic>Food Contamination</topic><topic>GENETIC EFFECTS</topic><topic>HAIR</topic><topic>Hair - analysis</topic><topic>hair mercury levels</topic><topic>Humans</topic><topic>INGESTION</topic><topic>INTAKE</topic><topic>LATIN AMERICA</topic><topic>Lymphocytes - ultrastructure</topic><topic>MAMMALS</topic><topic>MAN</topic><topic>MATERIALS</topic><topic>Medical sciences</topic><topic>MERCURY COMPOUNDS</topic><topic>METHYLMERCURY</topic><topic>Methylmercury Compounds - analysis</topic><topic>Methylmercury Compounds - blood</topic><topic>Methylmercury Compounds - pharmacology</topic><topic>MUTATION FREQUENCY</topic><topic>MUTATIONS</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC MERCURY COMPOUNDS</topic><topic>ORGANS</topic><topic>PRIMATES</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>sister chromatid exchange</topic><topic>Sister Chromatid Exchange - drug effects</topic><topic>SISTER CHROMATID EXCHANGES</topic><topic>SKIN</topic><topic>SOUTH AMERICA</topic><topic>Toxicology</topic><topic>VERTEBRATES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Monsalve, M. V.</creatorcontrib><creatorcontrib>Chiappe, C.</creatorcontrib><creatorcontrib>Universidad de los Andes, Bogota (Colombia)</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Environ. Mol. Mutagen.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Monsalve, M. V.</au><au>Chiappe, C.</au><aucorp>Universidad de los Andes, Bogota (Colombia)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic effects of methylmercury in human chromosomes: I. A cytogenetic study of people exposed through eating contaminated fish</atitle><jtitle>Environ. Mol. Mutagen.; (United States)</jtitle><addtitle>Environ. Mol. Mutagen</addtitle><date>1987</date><risdate>1987</risdate><volume>10</volume><issue>4</issue><spage>367</spage><epage>376</epage><pages>367-376</pages><issn>0893-6692</issn><eissn>1098-2280</eissn><coden>EMMUEG</coden><abstract>An analysis of chromosomal aberrations (structural and numerical) and sister chromatid exchange (SCE) was carried out on 16 people exposed to methylmercury through eating fish caught in Cartagena Bay (Colombia), an area of known methylmercury contamination. Fourteen people whose diet consisted mainly of fish caught in another, noncontaminated area of the Atlantic acted as controls. The results showed a significant difference between the experimental and control groups in methylmercury (MM) concentrations measured in hair and peripheral blood. Subsequently, significant differences between levels of organic mercury in blood and hair were found when all the individuals studied were classified in two groups according to their blood mercury levels. When achromatic lesions were included, the frequency of structural chromosome aberrations differed significantly between the exposed and control groups. Furthermore, a significant correlation (p < 0.05) was found between structural chromosome aberrations and groups (exposed and control). When achromatic lesions were excluded from the analyses, these differences were not found. There was a significant correlation between SCE and age. This is the first report of a study on the frequency of SCE in a population exposed to methylmercury.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>3678208</pmid><doi>10.1002/em.2850100406</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 0893-6692 |
| ispartof | Environ. Mol. Mutagen.; (United States), 1987, Vol.10 (4), p.367-376 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | 560300 - Chemicals Metabolism & Toxicology AGE DEPENDENCE ANIMALS AQUATIC ORGANISMS Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL MATERIALS BIOLOGY BLOOD blood mercury levels BODY BODY FLUIDS Chemical mutagenesis CHROMOSOMAL ABERRATIONS Chromosome Aberrations COLOMBIA CONTAMINATION CYTOLOGY DIET FISHES Food Contamination GENETIC EFFECTS HAIR Hair - analysis hair mercury levels Humans INGESTION INTAKE LATIN AMERICA Lymphocytes - ultrastructure MAMMALS MAN MATERIALS Medical sciences MERCURY COMPOUNDS METHYLMERCURY Methylmercury Compounds - analysis Methylmercury Compounds - blood Methylmercury Compounds - pharmacology MUTATION FREQUENCY MUTATIONS ORGANIC COMPOUNDS ORGANIC MERCURY COMPOUNDS ORGANS PRIMATES RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT sister chromatid exchange Sister Chromatid Exchange - drug effects SISTER CHROMATID EXCHANGES SKIN SOUTH AMERICA Toxicology VERTEBRATES |
| title | Genetic effects of methylmercury in human chromosomes: I. A cytogenetic study of people exposed through eating contaminated fish |
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