Sex-specific induction of mutations by PhIP in the kidney of male and female rats and its modulation by conjugated linoleic acid

The heterocyclic amine 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP) is a recognized mutagen and carcinogen in the colon and prostate of male rats and in the mammary gland of female rats. In the current study, we examined the mutagenicity of PhIP in the kidney of male and female lacI transg...

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Veröffentlicht in:	Environmental and molecular mutagenesis 2002, Vol.40 (2), p.116-121
Hauptverfasser:	Yang, Haiyan, Glickman, Barry W., de Boer, Johan G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Anticarcinogenic Agents - pharmacology antimutagenic Base Sequence Biological and medical sciences CLA Clonal Deletion - drug effects DNA Primers Female Fundamental and applied biological sciences. Psychology Gene Amplification Imidazoles - toxicity Isomerism kidney Kidney - drug effects Kidney - metabolism Linoleic Acid - pharmacology Male Molecular and cellular biology Molecular genetics Mutagenesis Mutagenesis. Repair Mutagenicity Tests Mutagens - toxicity mutation PhIP Polymerase Chain Reaction Rats Rats, Inbred F344 Sex Characteristics transgenic
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