Capillary electrophoresis, nuclear magnetic resonance and mass spectrometry studies of opposite chiral recognition of chlorpheniramine enantiomers with various cyclodextrins

Markedly different chiral separation abilities were observed for native β‐cyclodextrin (β‐CD), carboxymethyl‐β‐CD (CM‐β‐CD) and heptakis (2,3,6‐tri‐O‐methyl)‐β‐CD (TM‐β‐CD) towards the enantiomers of (±)‐chlorpheniramine ((±)‐CHL) in capillary electrophoresis (CE). Native β‐CD afforded almost baseli...

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