Synthesis of Zinc Tetraaminophthalocyanine Functionalized Graphene Nanosheets as an Enhanced Material for Sensitive Electrochemical Determination of Uric Acid
A new electrochemical sensor material has been fabricated via the non‐covalent functionalization of reduced graphene oxide (rGO) and soluble tetramino zincphthalocyanines (ZnPc‐NH2). Immobilization of uricase onto the synthesized nanohybrids can evidently improve the electrocatalytic activity and se...
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| Veröffentlicht in: | Electroanalysis (New York, N.Y.) N.Y.), 2020-07, Vol.32 (7), p.1507-1515 |
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| container_title | Electroanalysis (New York, N.Y.) |
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| creator | Shi, Yan‐mei Mei, Lin Zhang, Jun‐xia Hu, Kai Zhang, Xi Li, Zhu‐zhu Miao, Ming‐san Li, Xiu‐min |
| description | A new electrochemical sensor material has been fabricated via the non‐covalent functionalization of reduced graphene oxide (rGO) and soluble tetramino zincphthalocyanines (ZnPc‐NH2). Immobilization of uricase onto the synthesized nanohybrids can evidently improve the electrocatalytic activity and selectivity. The obtained composite membrane possesses a great enhancement of electron transfer rate and excellent synergistic electrocatalytic effect toward uric acid (UA) oxidation under the working potential at 0.620 V vs. Ag/AgCl with a scan rate of 0.125 V/s. The effects of the experimental parameters on the electrochemical oxidation responses of UA were investigated and optimized in detail. Under the optimized conditions, the peak currents were proportional to the UA concentration in a range from 0.5 to 100 μmol/L with detection limit of 0.15 μmol/L. Moreover, the developed sensor was applied for UA determination in human urine samples with high accuracy and satisfactory recovery, which is envisioned to have promising applications in monitoring UA in clinical research. |
| doi_str_mv | 10.1002/elan.201900748 |
| format | Article |
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Immobilization of uricase onto the synthesized nanohybrids can evidently improve the electrocatalytic activity and selectivity. The obtained composite membrane possesses a great enhancement of electron transfer rate and excellent synergistic electrocatalytic effect toward uric acid (UA) oxidation under the working potential at 0.620 V vs. Ag/AgCl with a scan rate of 0.125 V/s. The effects of the experimental parameters on the electrochemical oxidation responses of UA were investigated and optimized in detail. Under the optimized conditions, the peak currents were proportional to the UA concentration in a range from 0.5 to 100 μmol/L with detection limit of 0.15 μmol/L. Moreover, the developed sensor was applied for UA determination in human urine samples with high accuracy and satisfactory recovery, which is envisioned to have promising applications in monitoring UA in clinical research.</description><identifier>ISSN: 1040-0397</identifier><identifier>EISSN: 1521-4109</identifier><identifier>DOI: 10.1002/elan.201900748</identifier><language>eng</language><subject>Electrochemical sensor ; Non-covalent functionalization ; Reduced graphene oxide ; Uric Acid ; Zinc tetraaminophthalocyanine</subject><ispartof>Electroanalysis (New York, N.Y.), 2020-07, Vol.32 (7), p.1507-1515</ispartof><rights>2020 Wiley‐VCH Verlag GmbH & Co. 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Moreover, the developed sensor was applied for UA determination in human urine samples with high accuracy and satisfactory recovery, which is envisioned to have promising applications in monitoring UA in clinical research.</description><subject>Electrochemical sensor</subject><subject>Non-covalent functionalization</subject><subject>Reduced graphene oxide</subject><subject>Uric Acid</subject><subject>Zinc tetraaminophthalocyanine</subject><issn>1040-0397</issn><issn>1521-4109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFUE1LAzEQXUTBWr16zh_Ymux3jqW2Vaj10PbiZZlNJ2xkm5QkKuuP8beapaJHYWCGN--9GV4U3TI6YZQmd9iBniSUcUrLrDqLRixPWJwxys_DTDMa05SXl9GVc6-UUl5kfBR9bXrtW3TKESPJi9KCbNFbgIPS5tj6FjojetBKI1m8aeGV0dCpT9yTpYVjiwFfgzauRfSOQChN5roFLQLlCTxaBR2RxpINaqe8ekcy71B4a0SLByXC9h4DLRyEwX34Y2eVIFOh9tfRhYTO4c1PH0e7xXw7e4hXz8vH2XQVizQpqrjiLEk4QiMbKgXDPN-zhEssC1mkOS1lWsqqavIcMymqpAIoGpkLnjUBTQVLx9Hk5Cuscc6irI9WHcD2NaP1kG49pFv_phsE_CT4UB32_7Dr-Wq6_tN-A_tKg2Y</recordid><startdate>202007</startdate><enddate>202007</enddate><creator>Shi, Yan‐mei</creator><creator>Mei, Lin</creator><creator>Zhang, Jun‐xia</creator><creator>Hu, Kai</creator><creator>Zhang, Xi</creator><creator>Li, Zhu‐zhu</creator><creator>Miao, Ming‐san</creator><creator>Li, Xiu‐min</creator><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-9671-8038</orcidid></search><sort><creationdate>202007</creationdate><title>Synthesis of Zinc Tetraaminophthalocyanine Functionalized Graphene Nanosheets as an Enhanced Material for Sensitive Electrochemical Determination of Uric Acid</title><author>Shi, Yan‐mei ; Mei, Lin ; Zhang, Jun‐xia ; Hu, Kai ; Zhang, Xi ; Li, Zhu‐zhu ; Miao, Ming‐san ; Li, Xiu‐min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3268-891229eabfb0fc1e55d129fe76f63507f37f88b55e4fc828aa6bf5c94b88b3c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Electrochemical sensor</topic><topic>Non-covalent functionalization</topic><topic>Reduced graphene oxide</topic><topic>Uric Acid</topic><topic>Zinc tetraaminophthalocyanine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shi, Yan‐mei</creatorcontrib><creatorcontrib>Mei, Lin</creatorcontrib><creatorcontrib>Zhang, Jun‐xia</creatorcontrib><creatorcontrib>Hu, Kai</creatorcontrib><creatorcontrib>Zhang, Xi</creatorcontrib><creatorcontrib>Li, Zhu‐zhu</creatorcontrib><creatorcontrib>Miao, Ming‐san</creatorcontrib><creatorcontrib>Li, Xiu‐min</creatorcontrib><collection>CrossRef</collection><jtitle>Electroanalysis (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shi, Yan‐mei</au><au>Mei, Lin</au><au>Zhang, Jun‐xia</au><au>Hu, Kai</au><au>Zhang, Xi</au><au>Li, Zhu‐zhu</au><au>Miao, Ming‐san</au><au>Li, Xiu‐min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of Zinc Tetraaminophthalocyanine Functionalized Graphene Nanosheets as an Enhanced Material for Sensitive Electrochemical Determination of Uric Acid</atitle><jtitle>Electroanalysis (New York, N.Y.)</jtitle><date>2020-07</date><risdate>2020</risdate><volume>32</volume><issue>7</issue><spage>1507</spage><epage>1515</epage><pages>1507-1515</pages><issn>1040-0397</issn><eissn>1521-4109</eissn><abstract>A new electrochemical sensor material has been fabricated via the non‐covalent functionalization of reduced graphene oxide (rGO) and soluble tetramino zincphthalocyanines (ZnPc‐NH2). Immobilization of uricase onto the synthesized nanohybrids can evidently improve the electrocatalytic activity and selectivity. The obtained composite membrane possesses a great enhancement of electron transfer rate and excellent synergistic electrocatalytic effect toward uric acid (UA) oxidation under the working potential at 0.620 V vs. Ag/AgCl with a scan rate of 0.125 V/s. The effects of the experimental parameters on the electrochemical oxidation responses of UA were investigated and optimized in detail. Under the optimized conditions, the peak currents were proportional to the UA concentration in a range from 0.5 to 100 μmol/L with detection limit of 0.15 μmol/L. Moreover, the developed sensor was applied for UA determination in human urine samples with high accuracy and satisfactory recovery, which is envisioned to have promising applications in monitoring UA in clinical research.</abstract><doi>10.1002/elan.201900748</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-9671-8038</orcidid></addata></record> |
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| ispartof | Electroanalysis (New York, N.Y.), 2020-07, Vol.32 (7), p.1507-1515 |
| issn | 1040-0397 1521-4109 |
| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Electrochemical sensor Non-covalent functionalization Reduced graphene oxide Uric Acid Zinc tetraaminophthalocyanine |
| title | Synthesis of Zinc Tetraaminophthalocyanine Functionalized Graphene Nanosheets as an Enhanced Material for Sensitive Electrochemical Determination of Uric Acid |
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