Graphite Based Microsensors Developed for the Electrochemical Determination of L‐Tyrosine from Pharmaceutical Samples

Two electrochemical sensors were proposed for the determination of L‐tyrosine from pharmaceutical capsules. The electrochemical sensors were based on plain graphite paste and chitosan modified graphite paste. Working conditions, e. g. pH, supporting electrolytes have been optimized. The results reve...

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Veröffentlicht in:	Electroanalysis (New York, N.Y.) N.Y.), 2020-07, Vol.32 (7), p.1488-1497
Hauptverfasser:	Cioates Negut, Catalina, Stefanov, Cristina, Frederick van Staden, Jacobus (Koos)
Format:	Artikel
Sprache:	eng
Schlagworte:	chitosan differential pulse voltammetry graphite L-Tyrosine specific pharmaceutical capsules
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creator	Cioates Negut, Catalina Stefanov, Cristina Frederick van Staden, Jacobus (Koos)
description	Two electrochemical sensors were proposed for the determination of L‐tyrosine from pharmaceutical capsules. The electrochemical sensors were based on plain graphite paste and chitosan modified graphite paste. Working conditions, e. g. pH, supporting electrolytes have been optimized. The results revealed for both electrodes very low limits of quantification (LOQ) (0.18 mg L−1 and 0.0018 mg L−1) for plain graphite paste based sensors and for chitosan modified paste sensors respectively. A higher sensitivity of 7.95×10−10 A mg L−1 was obtained for the sensor based on plain graphite paste (G). The uniformity content test showed that L‐Tyrosine can be recovered in pharmaceutical capsules with an average value higher than 98.00 % and a relative standard deviation (RSD%) value less than 1.00 % (N=5).
doi_str_mv	10.1002/elan.201900733
format	Article
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The electrochemical sensors were based on plain graphite paste and chitosan modified graphite paste. Working conditions, e. g. pH, supporting electrolytes have been optimized. The results revealed for both electrodes very low limits of quantification (LOQ) (0.18 mg L−1 and 0.0018 mg L−1) for plain graphite paste based sensors and for chitosan modified paste sensors respectively. A higher sensitivity of 7.95×10−10 A mg L−1 was obtained for the sensor based on plain graphite paste (G). 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The electrochemical sensors were based on plain graphite paste and chitosan modified graphite paste. Working conditions, e. g. pH, supporting electrolytes have been optimized. The results revealed for both electrodes very low limits of quantification (LOQ) (0.18 mg L−1 and 0.0018 mg L−1) for plain graphite paste based sensors and for chitosan modified paste sensors respectively. A higher sensitivity of 7.95×10−10 A mg L−1 was obtained for the sensor based on plain graphite paste (G). 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The electrochemical sensors were based on plain graphite paste and chitosan modified graphite paste. Working conditions, e. g. pH, supporting electrolytes have been optimized. The results revealed for both electrodes very low limits of quantification (LOQ) (0.18 mg L−1 and 0.0018 mg L−1) for plain graphite paste based sensors and for chitosan modified paste sensors respectively. A higher sensitivity of 7.95×10−10 A mg L−1 was obtained for the sensor based on plain graphite paste (G). The uniformity content test showed that L‐Tyrosine can be recovered in pharmaceutical capsules with an average value higher than 98.00 % and a relative standard deviation (RSD%) value less than 1.00 % (N=5).</abstract><doi>10.1002/elan.201900733</doi><tpages>10</tpages></addata></record>
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subjects	chitosan differential pulse voltammetry graphite L-Tyrosine specific pharmaceutical capsules
title	Graphite Based Microsensors Developed for the Electrochemical Determination of L‐Tyrosine from Pharmaceutical Samples
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