Controlling Cyclopeptide Backbone Conformation with β/α-Hybrid Peptide-Heterocycle Scaffolds

Cyclopeptides (CPs) have been recognized as excellent templates for the rational design of biologically active compounds. However, in the absence of constraining elements, even the small cyclotetrapeptides (CTPs) and cyclopentapeptides (CPPs) may show conformational heterogeneity, with the occurrenc...

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Veröffentlicht in:	European journal of organic chemistry 2016-07, Vol.2016 (19), p.3243-3251
Hauptverfasser:	Gentilucci, Luca, Gallo, Francesca, Meloni, Fernanda, Mastandrea, Marco, Del Secco, Benedetta, De Marco, Rossella
Format:	Artikel
Sprache:	eng
Schlagworte:	Conformation analysis Cyclic peptides Macrocycles Peptides Peptidomimetics Secondary structure
Online-Zugang:	Volltext
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