A Common Synthetic Protocol for the Cyclic and Acyclic Core of Migrastatin, Isomigrastatin, and Dorrigocin via a Chiral β-Hydroxy-γ-butyrolactone Intermediate

A facile synthetic route has been developed for the synthesis of the cyclic and acyclic cores of migrastatin, isomigrastatin, and dorrigocin. The common synthetic route goes via a β‐hydroxy‐γ‐butyrolactone intermediate that is obtained by a PdII‐catalysed asymmetric allylic intramolecular cyclizatio...

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Veröffentlicht in:	European journal of organic chemistry 2014-10, Vol.2014 (29), p.6558-6564
Hauptverfasser:	Gade, Narendar Reddy, Iqbal, Javed
Format:	Artikel
Sprache:	eng
Schlagworte:	C-H activation Lactones Metathesis Natural products Oxidation Synthesis design
Online-Zugang:	Volltext
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