Chemoenzymatic Preparation of 1-Heteroarylethanamines of Low Solubility

Both enantiomers of biologically and pharmaceutically interesting benzofuran‐, benzothiophen‐, and phenylfuran‐based 1‐heteroarylethanamines were prepared at close to theoretical yields by using Candida antarctica lipase B (Novozym 435) catalyzed (R)‐selective N‐acylation with isopropyl butanoate (e...

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Veröffentlicht in:	European journal of organic chemistry 2012-06, Vol.2012 (17), p.3288-3294
Hauptverfasser:	Brem, Jürgen, Bencze, László-Csaba, Liljeblad, Arto, Turcu, Mihaela C., Paizs, Csaba, Irimie, Florin-Dan, Kanerva, Liisa T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylation Amides Asymmetric catalysis Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Chemistry Enantioselectivity Exact sciences and technology Fundamental and applied biological sciences. Psychology General and physical chemistry Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives Heterocyclic compounds with only one n hetero atom and condensed derivatives Hydrolysis Kinetic resolution Methods. Procedures. Technologies Organic chemistry Preparations and properties Solubility Solutions
Online-Zugang:	Volltext
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