1,2-Oxazines as Building Blocks for Stereoselective Synthesis: Preparation of Oxygen-Substituted 1,2-Oxazines, either by Alcohol Addition or by Epoxidation, and Subsequent Hydrogenation Leading to 1,2-Amino Alcohols and Pyrrolidines

Stereodefined oxygen‐substituted 1,2‐oxazines were prepared by three different routes. The cycloaddition of enol ethers such as 1 with α‐nitrosoalkenes generated in situ gave the heterocycles 3 and 4. Acid‐catalysed additions of alcohols to the 6H‐1,2‐oxazines 5 led to mixtures of the adducts 6 and...

Ausführliche Beschreibung