Efficient Sonogashira Coupling of Unprotected Halonucleosides in Aqueous Solvents Using Water-Soluble Palladium Catalysts

A variety of applications of C‐alkynylated nucleosides has prompted the continuing development of efficient synthetic methods for their preparation. We report an efficient andenvironmentally benign Sonogashira coupling reaction for alkynylation of unprotected halonucleosides in an aqueous solvent. T...

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Veröffentlicht in:	European Journal of Organic Chemistry 2010-07, Vol.2010 (19), p.3678-3683
Hauptverfasser:	Cho, Joon Hyung, Prickett, Caitlin D., Shaughnessy, Kevin H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbohydrates. Nucleosides and nucleotides Catalysis Catalysts: preparations and properties Chemistry Cross-coupling Exact sciences and technology General and physical chemistry Nitrogen heterocycles Nucleosides Nucleosides, nucleotides and oligonucleotides Organic chemistry Palladium Preparations and properties Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
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