Phosphane-Free Palladium-Catalyzed Carbonylative Suzuki Coupling Reaction of Aryl and Heteroaryl Iodides

The carbonylative cross‐coupling reaction of an arylboronic acid with an aryl iodide and a heteroaryl iodide to give unsymmetrical biaryl ketones was carried out by using Pd(tmhd)2/Pd(OAc)2 as a phosphane‐free catalyst. Various aryl and heteroaryl iodides with different arylboronic acid derivatives provided good to excellent yields of the desired products under optimized reaction conditions.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009) A facile protocol was developed for the synthesis of biaryl ketones through a carbonylative Suzuki coupling reaction with the use of Pd(tmhd)2/Pd(OAc)2 as a phosphane‐free catalyst. The catalytic system is applicable to carbonylative couplings of both aromatic and heteroaromatic aryliodides with various phenylboronic acids.