A Versatile Synthesis of 5′-Functionalized Nucleosides Through Regioselective Enzymatic Hydrolysis of Their Peracetylated Precursors

We describe a chemo‐enzymatic synthesis of modified nucleosides through lipase‐catalyzed hydrolysis of their peracetylated precursors. It was found from screening of a large number of substrates that these enzymes' regioselectivities were affected by the sugar and the nucleobase structures. By...

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Veröffentlicht in:	European Journal of Organic Chemistry 2009-04, Vol.2009 (12), p.1967-1975
Hauptverfasser:	Bavaro, Teodora, Rocchietti, Silvia, Ubiali, Daniela, Filice, Marco, Terreni, Marco, Pregnolato, Massimo
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Carbohydrates with 4, 5, 6, ... C atoms, dissacharides and oligosaccharides Carbohydrates. Nucleosides and nucleotides Chemistry Enzymes Exact sciences and technology Fundamental and applied biological sciences. Psychology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Immobilization Lipases Methods. Procedures. Technologies Nucleosides Nucleosides, nucleotides and oligonucleotides Organic chemistry Preparations and properties Regioselectivity
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