Perfluoroalkylation through Cross-Metathesis between Alkenes and (Perfluoroalkyl)propenes

A new approach to perfluoroalkylated compounds based on cross‐metathesis between perfluoropropenes and terminal alkenes has been developed. The reaction is catalysed with high efficiency and selectivity by the Hoveyda–Grubbs second‐generation catalyst under mild reaction conditions. The method is applicable to a wide range of compounds, such as vinylaromatics, isoprenoids and saccharides.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008) Perfluoroalkyl groups can be easily attached to various compounds under mild reaction conditions by cross‐metathesis between terminal alkenes and (perfluoroalkyl)propenes catalysed by the Hoveyda–Grubbs second‐generation catalysts.