Chemistry with [18F]Fluoride Ion
The success of molecular imaging with positron‐emission tomography (PET) depends on the availability of selective molecular probes labeled with positron‐emitters, such asfluorine‐18 (t1/2 = 109.7 min). No‐carrier‐added (NCA) [18F]fluoride ion (18F–) is the primary reagent for the preparation of 18F‐...
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| Veröffentlicht in: | European Journal of Organic Chemistry 2008-06, Vol.2008 (17), p.2853-2873 |
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| container_issue | 17 |
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| container_title | European Journal of Organic Chemistry |
| container_volume | 2008 |
| creator | Cai, Lisheng Lu, Shuiyu Pike, Victor W. |
| description | The success of molecular imaging with positron‐emission tomography (PET) depends on the availability of selective molecular probes labeled with positron‐emitters, such asfluorine‐18 (t1/2 = 109.7 min). No‐carrier‐added (NCA) [18F]fluoride ion (18F–) is the primary reagent for the preparation of 18F‐labeled tracers in high specific activity. In this microreview, we survey current and advancing radiochemical methods and technologies for the use of NCA [18F]fluoride ion in the preparation of 18F‐labeled radiotracers for applications with PET. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
The chemistry of cyclotron‐produced [18F]fluoride ion for producing [18F]fluoroalkyl or [18F]fluoroaryl compounds as radiotracers for molecular imaging with positron‐emission tomography is reviewed. |
| doi_str_mv | 10.1002/ejoc.200800114 |
| format | Article |
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The chemistry of cyclotron‐produced [18F]fluoride ion for producing [18F]fluoroalkyl or [18F]fluoroaryl compounds as radiotracers for molecular imaging with positron‐emission tomography is reviewed.</description><identifier>ISSN: 1434-193X</identifier><identifier>EISSN: 1099-0690</identifier><identifier>DOI: 10.1002/ejoc.200800114</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>[18F]Fluoride ion ; Fluorine-18 ; Labeling ; PET ; Radiotracer</subject><ispartof>European Journal of Organic Chemistry, 2008-06, Vol.2008 (17), p.2853-2873</ispartof><rights>Copyright © 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3274-befa107c22ed626f089087c0bfffa922a28b4b12fc9066539b4327735a4043833</citedby><cites>FETCH-LOGICAL-c3274-befa107c22ed626f089087c0bfffa922a28b4b12fc9066539b4327735a4043833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fejoc.200800114$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fejoc.200800114$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>313,314,780,784,792,1416,27920,27922,27923,45572,45573</link.rule.ids></links><search><creatorcontrib>Cai, Lisheng</creatorcontrib><creatorcontrib>Lu, Shuiyu</creatorcontrib><creatorcontrib>Pike, Victor W.</creatorcontrib><title>Chemistry with [18F]Fluoride Ion</title><title>European Journal of Organic Chemistry</title><addtitle>Eur. J. Org. Chem</addtitle><description>The success of molecular imaging with positron‐emission tomography (PET) depends on the availability of selective molecular probes labeled with positron‐emitters, such asfluorine‐18 (t1/2 = 109.7 min). No‐carrier‐added (NCA) [18F]fluoride ion (18F–) is the primary reagent for the preparation of 18F‐labeled tracers in high specific activity. In this microreview, we survey current and advancing radiochemical methods and technologies for the use of NCA [18F]fluoride ion in the preparation of 18F‐labeled radiotracers for applications with PET. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
The chemistry of cyclotron‐produced [18F]fluoride ion for producing [18F]fluoroalkyl or [18F]fluoroaryl compounds as radiotracers for molecular imaging with positron‐emission tomography is reviewed.</description><subject>[18F]Fluoride ion</subject><subject>Fluorine-18</subject><subject>Labeling</subject><subject>PET</subject><subject>Radiotracer</subject><issn>1434-193X</issn><issn>1099-0690</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqFz01Lw0AQgOFFFKzVq-f8gY2zH9mPo4SmVoMFUSyILJt0l6amRjYtNf_elEjx5mnmMM_Ai9A1gZgA0Bu3bsqYAigAQvgJGhHQGoPQcNrvnHFMNFuco4u2XQOAFoKMUJSu3KZqt6GL9tV2Fb0Rlb1n9a4J1dJFs-bzEp15W7fu6neO0Us2eU7vcD6fztLbHJeMSo4L5y0BWVLqloIKD0qDkiUU3nurKbVUFbwg1JcahEiYLnjvJEssB84UY2MUD3_L0LRtcN58hWpjQ2cImEOfOfSZY18P9AD2Ve26f67N5H6e_rV4sH25-z5aGz6MkEwm5vVxalSuFk9UPBjCfgBN4mD2</recordid><startdate>200806</startdate><enddate>200806</enddate><creator>Cai, Lisheng</creator><creator>Lu, Shuiyu</creator><creator>Pike, Victor W.</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200806</creationdate><title>Chemistry with [18F]Fluoride Ion</title><author>Cai, Lisheng ; Lu, Shuiyu ; Pike, Victor W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3274-befa107c22ed626f089087c0bfffa922a28b4b12fc9066539b4327735a4043833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>[18F]Fluoride ion</topic><topic>Fluorine-18</topic><topic>Labeling</topic><topic>PET</topic><topic>Radiotracer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cai, Lisheng</creatorcontrib><creatorcontrib>Lu, Shuiyu</creatorcontrib><creatorcontrib>Pike, Victor W.</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><jtitle>European Journal of Organic Chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cai, Lisheng</au><au>Lu, Shuiyu</au><au>Pike, Victor W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemistry with [18F]Fluoride Ion</atitle><jtitle>European Journal of Organic Chemistry</jtitle><addtitle>Eur. J. Org. Chem</addtitle><date>2008-06</date><risdate>2008</risdate><volume>2008</volume><issue>17</issue><spage>2853</spage><epage>2873</epage><pages>2853-2873</pages><issn>1434-193X</issn><eissn>1099-0690</eissn><abstract>The success of molecular imaging with positron‐emission tomography (PET) depends on the availability of selective molecular probes labeled with positron‐emitters, such asfluorine‐18 (t1/2 = 109.7 min). No‐carrier‐added (NCA) [18F]fluoride ion (18F–) is the primary reagent for the preparation of 18F‐labeled tracers in high specific activity. In this microreview, we survey current and advancing radiochemical methods and technologies for the use of NCA [18F]fluoride ion in the preparation of 18F‐labeled radiotracers for applications with PET. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
The chemistry of cyclotron‐produced [18F]fluoride ion for producing [18F]fluoroalkyl or [18F]fluoroaryl compounds as radiotracers for molecular imaging with positron‐emission tomography is reviewed.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><doi>10.1002/ejoc.200800114</doi><tpages>21</tpages></addata></record> |
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| language | eng |
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| subjects | [18F]Fluoride ion Fluorine-18 Labeling PET Radiotracer |
| title | Chemistry with [18F]Fluoride Ion |
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