A Practical Method for Selective Cleavage of a tert-Butoxycarbamoyl N-Protective Group from N,N-Diprotected α-Amino Acid Derivatives Using Montmorillonite K-10

A new, practical, and mild procedure for the selective cleavage of a tert‐butoxycarbonyl group (Boc) in N‐Boc‐N‐acyl‐diprotected amines is described. When applied to α‐amino acids, complete integrity of the stereochemistry was observed. The use of N,N‐di‐Boc‐α‐amino‐δ‐ and γ‐hydroxy esters provided...

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Veröffentlicht in:	European Journal of Organic Chemistry 2007-10, Vol.2007 (30), p.5050-05058
Hauptverfasser:	Hernández, J. Nicolás, Crisóstomo, Fernando R. Pinacho, Martín, Tomás, Martín, Víctor S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Asymmetric synthesis Clays Heterogeneous catalyst Lactones Protecting groups α-Amino acids
Online-Zugang:	Volltext
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