Efficient, Transition Metal Mediated, Sequential, Two- and Three-Component Coupling Reactions for the Synthesis of Highly Substituted Five-Membered Ring Carbocycles
A Cu‐catalysed method for the preparation of highly substituted methylenecyclopentanes, through a sequence involving a Michael addition of stabilized enolates to activated enynes followed by an intramolecular carbocupration reaction, is presented. This method was also successfully combined with a Pd...
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| Veröffentlicht in: | European Journal of Organic Chemistry 2007-07, Vol.2007 (19), p.3158-3165 |
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| container_end_page | 3165 |
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| container_issue | 19 |
| container_start_page | 3158 |
| container_title | European Journal of Organic Chemistry |
| container_volume | 2007 |
| creator | Coia, Nicolas Bouyssi, Didier Balme, Geneviève |
| description | A Cu‐catalysed method for the preparation of highly substituted methylenecyclopentanes, through a sequence involving a Michael addition of stabilized enolates to activated enynes followed by an intramolecular carbocupration reaction, is presented. This method was also successfully combined with a Pd‐mediated coupling reaction to perform a new three‐component reaction through a transmetallation pathway on the vinylcopper intermediate. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007) |
| doi_str_mv | 10.1002/ejoc.200700197 |
| format | Article |
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| ispartof | European Journal of Organic Chemistry, 2007-07, Vol.2007 (19), p.3158-3165 |
| issn | 1434-193X 1099-0690 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_ejoc_200700197 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Arylidenecyclopentanes Copper iodide Methylenecyclopentanes Multicomponent reactions Palladium Synthetic design |
| title | Efficient, Transition Metal Mediated, Sequential, Two- and Three-Component Coupling Reactions for the Synthesis of Highly Substituted Five-Membered Ring Carbocycles |
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