Synthesis of Aromatic Analogs of 8(S)-HETE and Their Biological Evaluation as Activators of the PPAR Nuclear Receptors

A new family of 8‐HETE analogs has been synthesized as dual PPAR α and γ agonists. A versatile strategy has been developed to allow modulations not only around the aromatic core but also on the side chains of these analogs. The affinity of these compounds towards the PPARα and PPARγ receptors is rep...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	European Journal of Organic Chemistry 2006-05, Vol.2006 (9), p.2181-2196
Hauptverfasser:	Caijo, Frédéric, Mosset, Paul, Grée, René, Audinot-Bouchez, Valérie, Boutin, Jean, Renard, Pierre, Caignard, Daniel-Henri, Dacquet, Catherine
Format:	Artikel
Sprache:	eng
Schlagworte:	8-HETE Diabetes Eicosanoids PPARs Stereoselective synthesis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!