Diastereoselective Synthesis of β-Amino-α-(trifluoromethyl) Alcohols from Homochiral α-Dibenzylamino Aldehydes

Homochiral α‐dibenzylamino aldehydes, prepared from the corresponding α‐amino acids, react with trimethyl(trifluoromethyl)silane in THF at 0 °C to afford, in good yields and dr, β‐amino‐α‐(trifluoromethyl) alcohols; anti diastereomers were formed as major products in the trifluoromethylation reactio...

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Veröffentlicht in:	European journal of organic chemistry 2004-04, Vol.2004 (7), p.1558-1566
Hauptverfasser:	Andrés, José M., Pedrosa, Rafael, Pérez-Encabo, Alfonso
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohols Amino aldehydes Asymmetric Synthesis Fluorine Trifluoromethylation
Online-Zugang:	Volltext
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