Synthesis and Molecular Modeling Studies of SYNPHOS®, a New, Efficient Diphosphane Ligand For Ruthenium-Catalyzed Asymmetric Hydrogenation

A new, optically active, atropisomeric diphosphane ligand, (2,3,2′,3′‐tetrahydro‐5,5′‐bi(1,4‐benzodioxin)‐6,6′‐diyl)bis‐(diphenylphosphane) (SYNPHOS®), has been synthesized, characterized, and used in ruthenium‐catalyzed asymmetric hydrogenations. This new ligand has been compared with other atropis...

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Veröffentlicht in:	European journal of organic chemistry 2003-05, Vol.2003 (10), p.1931-1941
Hauptverfasser:	Paule, Sébastien Duprat de, Jeulin, Séverine, Ratovelomanana-Vidal, Virginie, Genêt, Jean-Pierre, Champion, Nicolas, Dellis, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Asymmetric catalysis Atropisomerism Hydrogenation Molecular modeling Phosphanes Ruthenium
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container_issue	10
container_start_page	1931
container_title	European journal of organic chemistry
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creator	Paule, Sébastien Duprat de Jeulin, Séverine Ratovelomanana-Vidal, Virginie Genêt, Jean-Pierre Champion, Nicolas Dellis, Philippe
description	A new, optically active, atropisomeric diphosphane ligand, (2,3,2′,3′‐tetrahydro‐5,5′‐bi(1,4‐benzodioxin)‐6,6′‐diyl)bis‐(diphenylphosphane) (SYNPHOS®), has been synthesized, characterized, and used in ruthenium‐catalyzed asymmetric hydrogenations. This new ligand has been compared with other atropisomeric diphosphanes (BINAP and MeO‐BIPHEP) with respect to their dihedral angles calculated by molecular modeling and the enantioselectivity of their ruthenium‐mediated hydrogenation reactions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
doi_str_mv	10.1002/ejoc.200200634
format	Article
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subjects	Asymmetric catalysis Atropisomerism Hydrogenation Molecular modeling Phosphanes Ruthenium
title	Synthesis and Molecular Modeling Studies of SYNPHOS®, a New, Efficient Diphosphane Ligand For Ruthenium-Catalyzed Asymmetric Hydrogenation
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