Delivery of radioiodinated antisense oligonucleotides in long circulating liposomes in vivo

Delivery of radioiodinated antisense oligonucleotides in long circulating liposomes in vivo

The anionic long circulating liposomes (ALCLs) prepared in previous studies enabled high loading efficiency, small particle size, and good stability. In addition, the uptake by tumor cells and delivery of radioiodinated antisense oligonucleotides (ASON) to MCF‐7 breast cancer cell line was improved....

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Veröffentlicht in:European journal of lipid science and technology 2011-09, Vol.113 (9), p.1106-1112
Hauptverfasser: Ma, Chao, Lin, Jizheng, Xie, Jiawei, Wang, Guoming, Shuyao, Zuo
Format: Artikel
Sprache:eng
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Anionic
Antisense therapy
Biological and medical sciences
Fat industries
Food industries
Fundamental and applied biological sciences. Psychology
Long circulating liposomes
Radioiodine
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container_end_page 1112
container_issue 9
container_start_page 1106
container_title European journal of lipid science and technology
container_volume 113
creator Ma, Chao
Lin, Jizheng
Xie, Jiawei
Wang, Guoming
Shuyao, Zuo
description The anionic long circulating liposomes (ALCLs) prepared in previous studies enabled high loading efficiency, small particle size, and good stability. In addition, the uptake by tumor cells and delivery of radioiodinated antisense oligonucleotides (ASON) to MCF‐7 breast cancer cell line was improved. The liposomes also displayed valuable pharmacologic properties characterized by a long half‐life, slow clearance, and a significant area under the concentration–time curve (AUC) in vivo. This study emphasizes the contribution of ALCLs to the anti‐tumor effect of ASON and radiation therapy. Our results show that ALCLs improve biodistribution and delivery of radioiodinated ASON in tumor bearing rats, which is characterized by the suppression of tumor growth, decreased bcl‐2 expression, and increased tumor cell necrosis in the mammary tumor.
doi_str_mv 10.1002/ejlt.201000543
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subjects Anionic
Antisense therapy
Biological and medical sciences
Fat industries
Food industries
Fundamental and applied biological sciences. Psychology
Long circulating liposomes
Radioiodine
title Delivery of radioiodinated antisense oligonucleotides in long circulating liposomes in vivo
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