VEGFR2 is selectively expressed by FOXP3 high CD4 + Treg
CD25 + FOXP3 + CD4 + T cells (Treg) have been considered to play an important role in immune tolerance against several tumor antigens. It has also been indicated that high‐level expression of FOXP3 (FOXP3 high ) is sufficient to confer suppressive activity to normal non‐Treg. Here, we showed for the...
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| Veröffentlicht in: | European journal of immunology 2010-01, Vol.40 (1), p.197-203 |
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| container_title | European journal of immunology |
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| creator | Suzuki, Hiroyuki Onishi, Hideya Wada, Junji Yamasaki, Akio Tanaka, Haruo Nakano, Kenji Morisaki, Takashi Katano, Mitsuo |
| description | CD25
+
FOXP3
+
CD4
+
T cells (Treg) have been considered to play an important role in immune tolerance against several tumor antigens. It has also been indicated that high‐level expression of FOXP3 (FOXP3
high
) is sufficient to confer suppressive activity to normal non‐Treg. Here, we showed for the first time that vascular endothelial growth factor receptor 2 (VEGFR2) is selectively expressed by FOXP3
high
but not FOXP3
low
Treg. Such VEGFR2
+
Treg exist in several tissues including PBMC and malignant effusion‐derived lymphocytes. In conclusion, VEGFR2 may be a novel target for controlling Treg with highly suppressive function. |
| doi_str_mv | 10.1002/eji.200939887 |
| format | Article |
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+
FOXP3
+
CD4
+
T cells (Treg) have been considered to play an important role in immune tolerance against several tumor antigens. It has also been indicated that high‐level expression of FOXP3 (FOXP3
high
) is sufficient to confer suppressive activity to normal non‐Treg. Here, we showed for the first time that vascular endothelial growth factor receptor 2 (VEGFR2) is selectively expressed by FOXP3
high
but not FOXP3
low
Treg. Such VEGFR2
+
Treg exist in several tissues including PBMC and malignant effusion‐derived lymphocytes. In conclusion, VEGFR2 may be a novel target for controlling Treg with highly suppressive function.</description><identifier>ISSN: 0014-2980</identifier><identifier>EISSN: 1521-4141</identifier><identifier>DOI: 10.1002/eji.200939887</identifier><language>eng</language><ispartof>European journal of immunology, 2010-01, Vol.40 (1), p.197-203</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c827-92965445ec8ef96fd20767844d369cb1a76b456f259f08f42837d66e1d598c393</citedby><cites>FETCH-LOGICAL-c827-92965445ec8ef96fd20767844d369cb1a76b456f259f08f42837d66e1d598c393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Suzuki, Hiroyuki</creatorcontrib><creatorcontrib>Onishi, Hideya</creatorcontrib><creatorcontrib>Wada, Junji</creatorcontrib><creatorcontrib>Yamasaki, Akio</creatorcontrib><creatorcontrib>Tanaka, Haruo</creatorcontrib><creatorcontrib>Nakano, Kenji</creatorcontrib><creatorcontrib>Morisaki, Takashi</creatorcontrib><creatorcontrib>Katano, Mitsuo</creatorcontrib><title>VEGFR2 is selectively expressed by FOXP3 high CD4 + Treg</title><title>European journal of immunology</title><description>CD25
+
FOXP3
+
CD4
+
T cells (Treg) have been considered to play an important role in immune tolerance against several tumor antigens. It has also been indicated that high‐level expression of FOXP3 (FOXP3
high
) is sufficient to confer suppressive activity to normal non‐Treg. Here, we showed for the first time that vascular endothelial growth factor receptor 2 (VEGFR2) is selectively expressed by FOXP3
high
but not FOXP3
low
Treg. Such VEGFR2
+
Treg exist in several tissues including PBMC and malignant effusion‐derived lymphocytes. In conclusion, VEGFR2 may be a novel target for controlling Treg with highly suppressive function.</description><issn>0014-2980</issn><issn>1521-4141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNo9z89LwzAcBfAgCtbp0XvukvnN7-QodZ3CYCJFvJU2_WbrqDgSEfvfW1E8vcvjPT6EXHNYcgBxi4dhKQC89M7ZE1JwLThTXPFTUgBwxYR3cE4ucj7AXDPaF8S9rNbVs6BDphlHDB_DJ44Txa9jwpyxp91Eq-3rk6T7Yben5b2iN7ROuLskZ7EdM1795YLU1aouH9hmu34s7zYsOGGZF_ONUhqDw-hN7AVYY51SvTQ-dLy1plPaRKF9BBeVcNL2xiDvtXdBerkg7Hc2pPecE8bmmIa3Nk0Nh-ZH3czq5l8tvwGFgEbu</recordid><startdate>201001</startdate><enddate>201001</enddate><creator>Suzuki, Hiroyuki</creator><creator>Onishi, Hideya</creator><creator>Wada, Junji</creator><creator>Yamasaki, Akio</creator><creator>Tanaka, Haruo</creator><creator>Nakano, Kenji</creator><creator>Morisaki, Takashi</creator><creator>Katano, Mitsuo</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201001</creationdate><title>VEGFR2 is selectively expressed by FOXP3 high CD4 + Treg</title><author>Suzuki, Hiroyuki ; Onishi, Hideya ; Wada, Junji ; Yamasaki, Akio ; Tanaka, Haruo ; Nakano, Kenji ; Morisaki, Takashi ; Katano, Mitsuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c827-92965445ec8ef96fd20767844d369cb1a76b456f259f08f42837d66e1d598c393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suzuki, Hiroyuki</creatorcontrib><creatorcontrib>Onishi, Hideya</creatorcontrib><creatorcontrib>Wada, Junji</creatorcontrib><creatorcontrib>Yamasaki, Akio</creatorcontrib><creatorcontrib>Tanaka, Haruo</creatorcontrib><creatorcontrib>Nakano, Kenji</creatorcontrib><creatorcontrib>Morisaki, Takashi</creatorcontrib><creatorcontrib>Katano, Mitsuo</creatorcontrib><collection>CrossRef</collection><jtitle>European journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suzuki, Hiroyuki</au><au>Onishi, Hideya</au><au>Wada, Junji</au><au>Yamasaki, Akio</au><au>Tanaka, Haruo</au><au>Nakano, Kenji</au><au>Morisaki, Takashi</au><au>Katano, Mitsuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>VEGFR2 is selectively expressed by FOXP3 high CD4 + Treg</atitle><jtitle>European journal of immunology</jtitle><date>2010-01</date><risdate>2010</risdate><volume>40</volume><issue>1</issue><spage>197</spage><epage>203</epage><pages>197-203</pages><issn>0014-2980</issn><eissn>1521-4141</eissn><abstract>CD25
+
FOXP3
+
CD4
+
T cells (Treg) have been considered to play an important role in immune tolerance against several tumor antigens. It has also been indicated that high‐level expression of FOXP3 (FOXP3
high
) is sufficient to confer suppressive activity to normal non‐Treg. Here, we showed for the first time that vascular endothelial growth factor receptor 2 (VEGFR2) is selectively expressed by FOXP3
high
but not FOXP3
low
Treg. Such VEGFR2
+
Treg exist in several tissues including PBMC and malignant effusion‐derived lymphocytes. In conclusion, VEGFR2 may be a novel target for controlling Treg with highly suppressive function.</abstract><doi>10.1002/eji.200939887</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2980 |
| ispartof | European journal of immunology, 2010-01, Vol.40 (1), p.197-203 |
| issn | 0014-2980 1521-4141 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_eji_200939887 |
| source | Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content |
| title | VEGFR2 is selectively expressed by FOXP3 high CD4 + Treg |
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